Neurodegeneration across stages of cognitive decline in Parkinson disease

Daniel Weintraub, Jimit Doshi, Deepthi Koka, Christos Davatzikos, Andrew D. Siderowf, John E. Duda, David A. Wolk, Paul J. Moberg, Sharon X. Xie, Christopher M. Clark

Research output: Contribution to journalArticle

Abstract

Objective: To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD). Design: Images were quantified using a region-of-interest approach and voxel-based morphometry analysis. We used a high-dimensional pattern classification approach to delineate brain regions that collectively formed the Spatial Pattern of Abnormalities for Recognition of PDD. Setting: The Parkinson's Disease and Movement Disorders Center at the University of Pennsylvania. Subjects: Eighty-four PD patients (61 PD-NC, 12 PDMCI, and 11 PDD) and 23 healthy control subjects (HCs) underwent magnetic resonance imaging of the brain. Results: The PD-NC patients did not demonstrate significant brain atrophy compared with HCs. Compared with PD-NC patients, PD-MCI patients had hippocampal atrophy (β=-0.37; P=.001), and PDD patients demonstrated hippocampal (β=-0.32; P=.004) and additional medial temporal lobe atrophy (β=-0.36; P=.003). The PD-MCI patients had a different pattern of atrophy compared with PD-NC patients (P=.04) and a similar pattern to that of PDD patients (P=.81), characterized by hippocampal, prefrontal cortex gray and white matter, occipital lobe gray and white matter, and parietal lobe white matter atrophy. In nondemented PD patients, there was a correlation between memory-encoding performance and hippocampal volume. Conclusions: Hippocampal atrophy is a biomarker of initial cognitive decline in PD, including impaired memory encoding and storage, suggesting heterogeneity in the neural substrate of memory impairment. Use of a pattern classification approach may allow identification of diffuse regions of cortical gray and white matter atrophy early in the course of cognitive decline.

Original languageEnglish (US)
Pages (from-to)1562-1568
Number of pages7
JournalArchives of Neurology
Volume68
Issue number12
StatePublished - Dec 2011
Externally publishedYes

Fingerprint

Parkinson Disease
Atrophy
Brain
Cognitive Dysfunction
Parkinson's Disease
Occipital Lobe
Parietal Lobe
Movement Disorders
Temporal Lobe
Prefrontal Cortex
Cognition
Dementia
Healthy Volunteers
Biomarkers
Magnetic Resonance Imaging
White Matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Weintraub, D., Doshi, J., Koka, D., Davatzikos, C., Siderowf, A. D., Duda, J. E., ... Clark, C. M. (2011). Neurodegeneration across stages of cognitive decline in Parkinson disease. Archives of Neurology, 68(12), 1562-1568.

Neurodegeneration across stages of cognitive decline in Parkinson disease. / Weintraub, Daniel; Doshi, Jimit; Koka, Deepthi; Davatzikos, Christos; Siderowf, Andrew D.; Duda, John E.; Wolk, David A.; Moberg, Paul J.; Xie, Sharon X.; Clark, Christopher M.

In: Archives of Neurology, Vol. 68, No. 12, 12.2011, p. 1562-1568.

Research output: Contribution to journalArticle

Weintraub, D, Doshi, J, Koka, D, Davatzikos, C, Siderowf, AD, Duda, JE, Wolk, DA, Moberg, PJ, Xie, SX & Clark, CM 2011, 'Neurodegeneration across stages of cognitive decline in Parkinson disease', Archives of Neurology, vol. 68, no. 12, pp. 1562-1568.
Weintraub D, Doshi J, Koka D, Davatzikos C, Siderowf AD, Duda JE et al. Neurodegeneration across stages of cognitive decline in Parkinson disease. Archives of Neurology. 2011 Dec;68(12):1562-1568.
Weintraub, Daniel ; Doshi, Jimit ; Koka, Deepthi ; Davatzikos, Christos ; Siderowf, Andrew D. ; Duda, John E. ; Wolk, David A. ; Moberg, Paul J. ; Xie, Sharon X. ; Clark, Christopher M. / Neurodegeneration across stages of cognitive decline in Parkinson disease. In: Archives of Neurology. 2011 ; Vol. 68, No. 12. pp. 1562-1568.
@article{c61fa89fd025421189e0232ff61ac007,
title = "Neurodegeneration across stages of cognitive decline in Parkinson disease",
abstract = "Objective: To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD). Design: Images were quantified using a region-of-interest approach and voxel-based morphometry analysis. We used a high-dimensional pattern classification approach to delineate brain regions that collectively formed the Spatial Pattern of Abnormalities for Recognition of PDD. Setting: The Parkinson's Disease and Movement Disorders Center at the University of Pennsylvania. Subjects: Eighty-four PD patients (61 PD-NC, 12 PDMCI, and 11 PDD) and 23 healthy control subjects (HCs) underwent magnetic resonance imaging of the brain. Results: The PD-NC patients did not demonstrate significant brain atrophy compared with HCs. Compared with PD-NC patients, PD-MCI patients had hippocampal atrophy (β=-0.37; P=.001), and PDD patients demonstrated hippocampal (β=-0.32; P=.004) and additional medial temporal lobe atrophy (β=-0.36; P=.003). The PD-MCI patients had a different pattern of atrophy compared with PD-NC patients (P=.04) and a similar pattern to that of PDD patients (P=.81), characterized by hippocampal, prefrontal cortex gray and white matter, occipital lobe gray and white matter, and parietal lobe white matter atrophy. In nondemented PD patients, there was a correlation between memory-encoding performance and hippocampal volume. Conclusions: Hippocampal atrophy is a biomarker of initial cognitive decline in PD, including impaired memory encoding and storage, suggesting heterogeneity in the neural substrate of memory impairment. Use of a pattern classification approach may allow identification of diffuse regions of cortical gray and white matter atrophy early in the course of cognitive decline.",
author = "Daniel Weintraub and Jimit Doshi and Deepthi Koka and Christos Davatzikos and Siderowf, {Andrew D.} and Duda, {John E.} and Wolk, {David A.} and Moberg, {Paul J.} and Xie, {Sharon X.} and Clark, {Christopher M.}",
year = "2011",
month = "12",
language = "English (US)",
volume = "68",
pages = "1562--1568",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "12",

}

TY - JOUR

T1 - Neurodegeneration across stages of cognitive decline in Parkinson disease

AU - Weintraub, Daniel

AU - Doshi, Jimit

AU - Koka, Deepthi

AU - Davatzikos, Christos

AU - Siderowf, Andrew D.

AU - Duda, John E.

AU - Wolk, David A.

AU - Moberg, Paul J.

AU - Xie, Sharon X.

AU - Clark, Christopher M.

PY - 2011/12

Y1 - 2011/12

N2 - Objective: To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD). Design: Images were quantified using a region-of-interest approach and voxel-based morphometry analysis. We used a high-dimensional pattern classification approach to delineate brain regions that collectively formed the Spatial Pattern of Abnormalities for Recognition of PDD. Setting: The Parkinson's Disease and Movement Disorders Center at the University of Pennsylvania. Subjects: Eighty-four PD patients (61 PD-NC, 12 PDMCI, and 11 PDD) and 23 healthy control subjects (HCs) underwent magnetic resonance imaging of the brain. Results: The PD-NC patients did not demonstrate significant brain atrophy compared with HCs. Compared with PD-NC patients, PD-MCI patients had hippocampal atrophy (β=-0.37; P=.001), and PDD patients demonstrated hippocampal (β=-0.32; P=.004) and additional medial temporal lobe atrophy (β=-0.36; P=.003). The PD-MCI patients had a different pattern of atrophy compared with PD-NC patients (P=.04) and a similar pattern to that of PDD patients (P=.81), characterized by hippocampal, prefrontal cortex gray and white matter, occipital lobe gray and white matter, and parietal lobe white matter atrophy. In nondemented PD patients, there was a correlation between memory-encoding performance and hippocampal volume. Conclusions: Hippocampal atrophy is a biomarker of initial cognitive decline in PD, including impaired memory encoding and storage, suggesting heterogeneity in the neural substrate of memory impairment. Use of a pattern classification approach may allow identification of diffuse regions of cortical gray and white matter atrophy early in the course of cognitive decline.

AB - Objective: To assess regions and patterns of brain atrophy in patients with Parkinson disease (PD) with normal cognition (PD-NC), mild cognitive impairment (PD-MCI), and dementia-level cognitive deficits (PDD). Design: Images were quantified using a region-of-interest approach and voxel-based morphometry analysis. We used a high-dimensional pattern classification approach to delineate brain regions that collectively formed the Spatial Pattern of Abnormalities for Recognition of PDD. Setting: The Parkinson's Disease and Movement Disorders Center at the University of Pennsylvania. Subjects: Eighty-four PD patients (61 PD-NC, 12 PDMCI, and 11 PDD) and 23 healthy control subjects (HCs) underwent magnetic resonance imaging of the brain. Results: The PD-NC patients did not demonstrate significant brain atrophy compared with HCs. Compared with PD-NC patients, PD-MCI patients had hippocampal atrophy (β=-0.37; P=.001), and PDD patients demonstrated hippocampal (β=-0.32; P=.004) and additional medial temporal lobe atrophy (β=-0.36; P=.003). The PD-MCI patients had a different pattern of atrophy compared with PD-NC patients (P=.04) and a similar pattern to that of PDD patients (P=.81), characterized by hippocampal, prefrontal cortex gray and white matter, occipital lobe gray and white matter, and parietal lobe white matter atrophy. In nondemented PD patients, there was a correlation between memory-encoding performance and hippocampal volume. Conclusions: Hippocampal atrophy is a biomarker of initial cognitive decline in PD, including impaired memory encoding and storage, suggesting heterogeneity in the neural substrate of memory impairment. Use of a pattern classification approach may allow identification of diffuse regions of cortical gray and white matter atrophy early in the course of cognitive decline.

UR - http://www.scopus.com/inward/record.url?scp=83455225206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83455225206&partnerID=8YFLogxK

M3 - Article

VL - 68

SP - 1562

EP - 1568

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 12

ER -