Neurocysticercosis: Unraveling the nature of the single cysticercal granuloma

H. H. García, Armandoe Gonzalez, S. Rodriguez, V. C W Tsang, E. J. Pretell, I. Gonzales, Robert H Gilman

Research output: Contribution to journalArticle

Abstract

A single enhancing lesion in the brain parenchyma, also called an inflammatory granuloma, is a frequent neurologic diagnosis. One of the commonest causes of this lesion is human neurocysticercosis, the infection by the larvae of the pork tapeworm, Taenia solium. Following the demonstration that viable cysticercosis cysts survive in good conditions for several years in the human brain, single cysticercal granulomas have been consistently interpreted as representing late degeneration of a long-established parasite. On the basis of epidemiologic, clinical, and laboratory evidence detailed in this article, we hypothesize that in most cases these inflammatory lesions correspond to parasites that die in the early steps of infection, likely as the natural result of the host immunity overcoming mild infections.

Original languageEnglish (US)
Pages (from-to)654-658
Number of pages5
JournalNeurology
Volume75
Issue number7
DOIs
StatePublished - Aug 17 2010

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Neurocysticercosis
Granuloma
Taenia solium
Parasites
Infection
Cysticercosis
Brain
Nervous System
Larva
Cysts
Immunity

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Neurocysticercosis : Unraveling the nature of the single cysticercal granuloma. / García, H. H.; Gonzalez, Armandoe; Rodriguez, S.; Tsang, V. C W; Pretell, E. J.; Gonzales, I.; Gilman, Robert H.

In: Neurology, Vol. 75, No. 7, 17.08.2010, p. 654-658.

Research output: Contribution to journalArticle

García, HH, Gonzalez, A, Rodriguez, S, Tsang, VCW, Pretell, EJ, Gonzales, I & Gilman, RH 2010, 'Neurocysticercosis: Unraveling the nature of the single cysticercal granuloma', Neurology, vol. 75, no. 7, pp. 654-658. https://doi.org/10.1212/WNL.0b013e3181ed9eae
García HH, Gonzalez A, Rodriguez S, Tsang VCW, Pretell EJ, Gonzales I et al. Neurocysticercosis: Unraveling the nature of the single cysticercal granuloma. Neurology. 2010 Aug 17;75(7):654-658. https://doi.org/10.1212/WNL.0b013e3181ed9eae
García, H. H. ; Gonzalez, Armandoe ; Rodriguez, S. ; Tsang, V. C W ; Pretell, E. J. ; Gonzales, I. ; Gilman, Robert H. / Neurocysticercosis : Unraveling the nature of the single cysticercal granuloma. In: Neurology. 2010 ; Vol. 75, No. 7. pp. 654-658.
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