Neurocognitive impairment influences quality of life in HIV-infected patients receiving HAART

V. Tozzi, P. Balestra, R. Murri, S. Galgani, R. Bellagamba, P. Narciso, A. Antinori, M. Giulianelli, G. Tosi, M. Fantoni, A. Sampaolesi, P. Noto, G. Ippolito, A. W. Wu

Research output: Contribution to journalArticlepeer-review


The objective of the study was to determine the association of neurocognitive impairment with health-related quality of life (HRQoL) in patients receiving highly active antiretroviral therapy (HAART). Seventy subjects were cross-sectionally analysed with a standardized neuropsychological test battery and a questionnaire including an Italian translation of the MOS-HIV Health Survey. The presence of neurocognitive impairment was significantly associated with lower HRQoL scores: pain (P = 0.03), physical functioning (P = 0.01), role functioning (P = 0.01), social functioning (P = 0.029), mental health (P = 0.001), energy (P = 0.036), health distress (P = 0.002), cognitive functioning (P = 0.05), current health perception (P < 0.001), physical health summary score (PHS) (P = 0.005), mental health summary score (MHS) (P = 0.002). Years of education (odds ratio [OR] 0.79; 95% confidence interval [CI] 0.65-0.96), PHS (OR 0.71; 95% CI 0.54-0.95) and MHS (OR 0.67; 95% CI 0.51-0.88) were also associated with cognitive impairment. Neurocognitive impairment in patients receiving HAART was associated with reduced HRQoL. Identifying cognitive impairment may provide motivation for additional treatment to help patients to compensate for deficits in functioning.

Original languageEnglish (US)
Pages (from-to)254-259
Number of pages6
JournalInternational Journal of STD and AIDS
Issue number4
StatePublished - Apr 2004


  • HIV
  • Highly active antiretroviral therapy
  • Neurocognitive impairment
  • Quality of life

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Pharmacology (medical)


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