TY - JOUR
T1 - Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives
T2 - A review of the literature
AU - Cardenas, Stephanie A.
AU - Kassem, Layla
AU - Brotman, Melissa A.
AU - Leibenluft, Ellen
AU - McMahon, Francis J.
N1 - Funding Information:
This work was funded by the NIMH Intramural Research Program ( 1Z01MH002810-11 ).
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background Neurocognitive deficits are present in bipolar disorder (BD) patients and their unaffected (nonbipolar) relatives, but it is not clear which domains are most often impaired and the extent of the impairment resulting from shared genetic factors. In this literature review, we address these issues and identify specific neurocognitive tasks most sensitive to cognitive deficits in patients and unaffected relatives. Method We conducted a systematic review in Web of Science, PubMed/Medline and PsycINFO databases. Results Fifty-one articles assessing cognitive functioning in BD patients (23 studies) and unaffected relatives (28 studies) were examined. Patients and, less so, relatives show impairments in attention, processing speed, verbal learning/memory, and verbal fluency. Conclusion Studies were more likely to find impairment in patients than relatives, suggesting that some neurocognitive deficits may be a result of the illness itself and/or its treatment. However, small sample sizes, differences among relatives studied (e.g., relatedness, diagnostic status, age), and differences in assessment instruments may contribute to inconsistencies in reported neurocognitive performance among relatives. Additional studies addressing these issues are needed.
AB - Background Neurocognitive deficits are present in bipolar disorder (BD) patients and their unaffected (nonbipolar) relatives, but it is not clear which domains are most often impaired and the extent of the impairment resulting from shared genetic factors. In this literature review, we address these issues and identify specific neurocognitive tasks most sensitive to cognitive deficits in patients and unaffected relatives. Method We conducted a systematic review in Web of Science, PubMed/Medline and PsycINFO databases. Results Fifty-one articles assessing cognitive functioning in BD patients (23 studies) and unaffected relatives (28 studies) were examined. Patients and, less so, relatives show impairments in attention, processing speed, verbal learning/memory, and verbal fluency. Conclusion Studies were more likely to find impairment in patients than relatives, suggesting that some neurocognitive deficits may be a result of the illness itself and/or its treatment. However, small sample sizes, differences among relatives studied (e.g., relatedness, diagnostic status, age), and differences in assessment instruments may contribute to inconsistencies in reported neurocognitive performance among relatives. Additional studies addressing these issues are needed.
KW - At-risk
KW - Bipolar disorder
KW - Cognition
KW - Neuropsychology
KW - Relatives
KW - Review
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U2 - 10.1016/j.neubiorev.2016.08.002
DO - 10.1016/j.neubiorev.2016.08.002
M3 - Review article
C2 - 27502749
AN - SCOPUS:84981549546
SN - 0149-7634
VL - 69
SP - 193
EP - 215
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -