Neurocognitive Effects of Aluminum

Brian S. Schwartz, Karen I. Bolla, Lisa Wieler, Janice Herron, Gary Briefel, David Spector, Louis Gimenez

Research output: Contribution to journalArticlepeer-review

Abstract

The neurocognitive effects of aluminum (Al) were studied in 35 hemodialysis patients. Higher Al levels were associated with a decline in visual memory. As Al levels increased, patients with lower vocabulary scores (a measure of premorbid intelligence) showed a decline in attention/concentration, frontal lobe functions, and on several neurocognitive measures, while those with higher vocabulary scores revealed no Al-related decline. These results suggest that individuals with lower verbal intelligence may possess less well-developed compensatory strategies to overcome the neurocognitive effects associated with Al. These data also indicate that Al is neurotoxic and, therefore, potential sources of environmental Al should be identified and eliminated.

Original languageEnglish (US)
Pages (from-to)1021-1026
Number of pages6
JournalArchives of neurology
Volume49
Issue number10
DOIs
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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