Neurocognitive Effects of Aluminum

Brian S. Schwartz; Karen I. Bolla; Lisa Wieler; Janice Herron; Gary Briefel; David Spector; Louis Gimenez

doi:10.1001/archneur.1992.00530340037015

Neurocognitive Effects of Aluminum

Brian S. Schwartz, Karen I. Bolla, Lisa Wieler, Janice Herron, Gary Briefel, David Spector, Louis Gimenez

Research output: Contribution to journal › Article › peer-review

Abstract

The neurocognitive effects of aluminum (Al) were studied in 35 hemodialysis patients. Higher Al levels were associated with a decline in visual memory. As Al levels increased, patients with lower vocabulary scores (a measure of premorbid intelligence) showed a decline in attention/concentration, frontal lobe functions, and on several neurocognitive measures, while those with higher vocabulary scores revealed no Al-related decline. These results suggest that individuals with lower verbal intelligence may possess less well-developed compensatory strategies to overcome the neurocognitive effects associated with Al. These data also indicate that Al is neurotoxic and, therefore, potential sources of environmental Al should be identified and eliminated.

Original language	English (US)
Pages (from-to)	1021-1026
Number of pages	6
Journal	Archives of neurology
Volume	49
Issue number	10
DOIs	https://doi.org/10.1001/archneur.1992.00530340037015
State	Published - Oct 1992

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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10.1001/archneur.1992.00530340037015

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abstract = "The neurocognitive effects of aluminum (Al) were studied in 35 hemodialysis patients. Higher Al levels were associated with a decline in visual memory. As Al levels increased, patients with lower vocabulary scores (a measure of premorbid intelligence) showed a decline in attention/concentration, frontal lobe functions, and on several neurocognitive measures, while those with higher vocabulary scores revealed no Al-related decline. These results suggest that individuals with lower verbal intelligence may possess less well-developed compensatory strategies to overcome the neurocognitive effects associated with Al. These data also indicate that Al is neurotoxic and, therefore, potential sources of environmental Al should be identified and eliminated.",

author = "Schwartz, {Brian S.} and Bolla, {Karen I.} and Lisa Wieler and Janice Herron and Gary Briefel and David Spector and Louis Gimenez",

year = "1992",

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AU - Schwartz, Brian S.

AU - Bolla, Karen I.

AU - Wieler, Lisa

AU - Herron, Janice

AU - Briefel, Gary

AU - Spector, David

AU - Gimenez, Louis

PY - 1992/10

Y1 - 1992/10

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AB - The neurocognitive effects of aluminum (Al) were studied in 35 hemodialysis patients. Higher Al levels were associated with a decline in visual memory. As Al levels increased, patients with lower vocabulary scores (a measure of premorbid intelligence) showed a decline in attention/concentration, frontal lobe functions, and on several neurocognitive measures, while those with higher vocabulary scores revealed no Al-related decline. These results suggest that individuals with lower verbal intelligence may possess less well-developed compensatory strategies to overcome the neurocognitive effects associated with Al. These data also indicate that Al is neurotoxic and, therefore, potential sources of environmental Al should be identified and eliminated.

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Neurocognitive Effects of Aluminum

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