TY - JOUR
T1 - Neurocognitive Effects of Aluminum
AU - Schwartz, Brian S.
AU - Bolla, Karen I.
AU - Wieler, Lisa
AU - Herron, Janice
AU - Briefel, Gary
AU - Spector, David
AU - Gimenez, Louis
PY - 1992/10
Y1 - 1992/10
N2 - The neurocognitive effects of aluminum (Al) were studied in 35 hemodialysis patients. Higher Al levels were associated with a decline in visual memory. As Al levels increased, patients with lower vocabulary scores (a measure of premorbid intelligence) showed a decline in attention/concentration, frontal lobe functions, and on several neurocognitive measures, while those with higher vocabulary scores revealed no Al-related decline. These results suggest that individuals with lower verbal intelligence may possess less well-developed compensatory strategies to overcome the neurocognitive effects associated with Al. These data also indicate that Al is neurotoxic and, therefore, potential sources of environmental Al should be identified and eliminated.
AB - The neurocognitive effects of aluminum (Al) were studied in 35 hemodialysis patients. Higher Al levels were associated with a decline in visual memory. As Al levels increased, patients with lower vocabulary scores (a measure of premorbid intelligence) showed a decline in attention/concentration, frontal lobe functions, and on several neurocognitive measures, while those with higher vocabulary scores revealed no Al-related decline. These results suggest that individuals with lower verbal intelligence may possess less well-developed compensatory strategies to overcome the neurocognitive effects associated with Al. These data also indicate that Al is neurotoxic and, therefore, potential sources of environmental Al should be identified and eliminated.
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U2 - 10.1001/archneur.1992.00530340037015
DO - 10.1001/archneur.1992.00530340037015
M3 - Article
C2 - 1417509
AN - SCOPUS:0026754491
VL - 49
SP - 1021
EP - 1026
JO - Archives of Neurology
JF - Archives of Neurology
SN - 0003-9942
IS - 10
ER -