Neurochemical similarities between d,l-cathinone and d-amphetamine

G. C. Wagner, K. Preston, George Ricaurte, C. R. Schuster, L. S. Seiden

Research output: Contribution to journalArticle

Abstract

Cathinone, the principal alkaloid of Khat, was compared to the psychomotor stimulant d-amphetamine on a number of neurochemical measures. Like d-amphetamine, d,l-cathinone released and blocked the uptake of tritiated dopamine (DA) in synaptosomal preparations. In addition, repeated high doses of d,l-cathinone produced long-lasting DA depletions in various rat brain regions and decreased the number of synaptosomal DA uptake sites in a manner similar to that seen after repeated d-amphetamine administration. Importantly, this DA neurotoxic effect of d,l-cathinone, like that of d-amphetamine, is selective since regional brain levels of norepinephrine (NE) or serotonin (5-HT) are not altered on a long-term basis by repeated administration of d,l-cathinone. These findings are discussed with reference to the current practice of Khat leaf chewing by people in north-eastern Africa.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalDrug and Alcohol Dependence
Volume9
Issue number4
DOIs
StatePublished - 1982
Externally publishedYes

Fingerprint

Dextroamphetamine
brain
Dopamine
Catha
Brain
Serotonin
Mastication
Northern Africa
Eastern Africa
Dopamine Agents
Alkaloids
Rats
Norepinephrine
cathinone

ASJC Scopus subject areas

  • Medicine(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Neurochemical similarities between d,l-cathinone and d-amphetamine. / Wagner, G. C.; Preston, K.; Ricaurte, George; Schuster, C. R.; Seiden, L. S.

In: Drug and Alcohol Dependence, Vol. 9, No. 4, 1982, p. 279-284.

Research output: Contribution to journalArticle

Wagner, G. C. ; Preston, K. ; Ricaurte, George ; Schuster, C. R. ; Seiden, L. S. / Neurochemical similarities between d,l-cathinone and d-amphetamine. In: Drug and Alcohol Dependence. 1982 ; Vol. 9, No. 4. pp. 279-284.
@article{8192bd00a4394854bb049a788776e24a,
title = "Neurochemical similarities between d,l-cathinone and d-amphetamine",
abstract = "Cathinone, the principal alkaloid of Khat, was compared to the psychomotor stimulant d-amphetamine on a number of neurochemical measures. Like d-amphetamine, d,l-cathinone released and blocked the uptake of tritiated dopamine (DA) in synaptosomal preparations. In addition, repeated high doses of d,l-cathinone produced long-lasting DA depletions in various rat brain regions and decreased the number of synaptosomal DA uptake sites in a manner similar to that seen after repeated d-amphetamine administration. Importantly, this DA neurotoxic effect of d,l-cathinone, like that of d-amphetamine, is selective since regional brain levels of norepinephrine (NE) or serotonin (5-HT) are not altered on a long-term basis by repeated administration of d,l-cathinone. These findings are discussed with reference to the current practice of Khat leaf chewing by people in north-eastern Africa.",
author = "Wagner, {G. C.} and K. Preston and George Ricaurte and Schuster, {C. R.} and Seiden, {L. S.}",
year = "1982",
doi = "10.1016/0376-8716(82)90067-9",
language = "English (US)",
volume = "9",
pages = "279--284",
journal = "Drug and Alcohol Dependence",
issn = "0376-8716",
publisher = "Elsevier Ireland Ltd",
number = "4",

}

TY - JOUR

T1 - Neurochemical similarities between d,l-cathinone and d-amphetamine

AU - Wagner, G. C.

AU - Preston, K.

AU - Ricaurte, George

AU - Schuster, C. R.

AU - Seiden, L. S.

PY - 1982

Y1 - 1982

N2 - Cathinone, the principal alkaloid of Khat, was compared to the psychomotor stimulant d-amphetamine on a number of neurochemical measures. Like d-amphetamine, d,l-cathinone released and blocked the uptake of tritiated dopamine (DA) in synaptosomal preparations. In addition, repeated high doses of d,l-cathinone produced long-lasting DA depletions in various rat brain regions and decreased the number of synaptosomal DA uptake sites in a manner similar to that seen after repeated d-amphetamine administration. Importantly, this DA neurotoxic effect of d,l-cathinone, like that of d-amphetamine, is selective since regional brain levels of norepinephrine (NE) or serotonin (5-HT) are not altered on a long-term basis by repeated administration of d,l-cathinone. These findings are discussed with reference to the current practice of Khat leaf chewing by people in north-eastern Africa.

AB - Cathinone, the principal alkaloid of Khat, was compared to the psychomotor stimulant d-amphetamine on a number of neurochemical measures. Like d-amphetamine, d,l-cathinone released and blocked the uptake of tritiated dopamine (DA) in synaptosomal preparations. In addition, repeated high doses of d,l-cathinone produced long-lasting DA depletions in various rat brain regions and decreased the number of synaptosomal DA uptake sites in a manner similar to that seen after repeated d-amphetamine administration. Importantly, this DA neurotoxic effect of d,l-cathinone, like that of d-amphetamine, is selective since regional brain levels of norepinephrine (NE) or serotonin (5-HT) are not altered on a long-term basis by repeated administration of d,l-cathinone. These findings are discussed with reference to the current practice of Khat leaf chewing by people in north-eastern Africa.

UR - http://www.scopus.com/inward/record.url?scp=0019919651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019919651&partnerID=8YFLogxK

U2 - 10.1016/0376-8716(82)90067-9

DO - 10.1016/0376-8716(82)90067-9

M3 - Article

C2 - 7128450

AN - SCOPUS:0019919651

VL - 9

SP - 279

EP - 284

JO - Drug and Alcohol Dependence

JF - Drug and Alcohol Dependence

SN - 0376-8716

IS - 4

ER -