TY - JOUR
T1 - Neurochemical similarities between d,l-cathinone and d-amphetamine
AU - Wagner, G. C.
AU - Preston, K.
AU - Ricaurte, G. A.
AU - Schuster, C. R.
AU - Seiden, L. S.
N1 - Funding Information:
This study was supported in part by USPHS NIDA grants DA 00250 and 00085. In addition G. C. Wagner was supported by a Searle Fellowship. K. Preston was supported by grant PH55-T32 9M-07151 from the National Institute of General Medical Health, and G. A. Ricaurte was supported by an Insurance Medical Scientist Training Fund (New York Life). We wish to thank Dr. Inayat Khan of the World Health Organization for supplying the cathinone.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1982/8
Y1 - 1982/8
N2 - Cathinone, the principal alkaloid of Khat, was compared to the psychomotor stimulant d-amphetamine on a number of neurochemical measures. Like d-amphetamine, d,l-cathinone released and blocked the uptake of tritiated dopamine (DA) in synaptosomal preparations. In addition, repeated high doses of d,l-cathinone produced long-lasting DA depletions in various rat brain regions and decreased the number of synaptosomal DA uptake sites in a manner similar to that seen after repeated d-amphetamine administration. Importantly, this DA neurotoxic effect of d,l-cathinone, like that of d-amphetamine, is selective since regional brain levels of norepinephrine (NE) or serotonin (5-HT) are not altered on a long-term basis by repeated administration of d,l-cathinone. These findings are discussed with reference to the current practice of Khat leaf chewing by people in north-eastern Africa.
AB - Cathinone, the principal alkaloid of Khat, was compared to the psychomotor stimulant d-amphetamine on a number of neurochemical measures. Like d-amphetamine, d,l-cathinone released and blocked the uptake of tritiated dopamine (DA) in synaptosomal preparations. In addition, repeated high doses of d,l-cathinone produced long-lasting DA depletions in various rat brain regions and decreased the number of synaptosomal DA uptake sites in a manner similar to that seen after repeated d-amphetamine administration. Importantly, this DA neurotoxic effect of d,l-cathinone, like that of d-amphetamine, is selective since regional brain levels of norepinephrine (NE) or serotonin (5-HT) are not altered on a long-term basis by repeated administration of d,l-cathinone. These findings are discussed with reference to the current practice of Khat leaf chewing by people in north-eastern Africa.
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U2 - 10.1016/0376-8716(82)90067-9
DO - 10.1016/0376-8716(82)90067-9
M3 - Article
C2 - 7128450
AN - SCOPUS:0019919651
SN - 0376-8716
VL - 9
SP - 279
EP - 284
JO - Drug and alcohol dependence
JF - Drug and alcohol dependence
IS - 4
ER -