Neuroblastoma: When differentiation goes awry

Maged Zeineldin; Anand G. Patel; Michael A. Dyer

doi:10.1016/j.neuron.2022.07.012

Neuroblastoma: When differentiation goes awry

Maged Zeineldin, Anand G. Patel, Michael A. Dyer

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage contributes to neuroblastoma formation. The developmental arrest of these cell types explains many biological features of the disease, including its cellular heterogeneity, mutational spectrum, spontaneous regression, and response to drugs that induce tumor cell differentiation. In this review, we provide evidence that supports the notion that arrested neural-crest-derived progenitor cells give rise to neuroblastoma and discuss how this concept could be exploited for clinical management of the disease.

Original language	English (US)
Pages (from-to)	2916-2928
Number of pages	13
Journal	Neuron
Volume	110
Issue number	18
DOIs	https://doi.org/10.1016/j.neuron.2022.07.012
State	Published - Sep 21 2022

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2022.07.012

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title = "Neuroblastoma: When differentiation goes awry",

abstract = "Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage contributes to neuroblastoma formation. The developmental arrest of these cell types explains many biological features of the disease, including its cellular heterogeneity, mutational spectrum, spontaneous regression, and response to drugs that induce tumor cell differentiation. In this review, we provide evidence that supports the notion that arrested neural-crest-derived progenitor cells give rise to neuroblastoma and discuss how this concept could be exploited for clinical management of the disease.",

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AU - Dyer, Michael A.

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N2 - Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage contributes to neuroblastoma formation. The developmental arrest of these cell types explains many biological features of the disease, including its cellular heterogeneity, mutational spectrum, spontaneous regression, and response to drugs that induce tumor cell differentiation. In this review, we provide evidence that supports the notion that arrested neural-crest-derived progenitor cells give rise to neuroblastoma and discuss how this concept could be exploited for clinical management of the disease.

AB - Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage contributes to neuroblastoma formation. The developmental arrest of these cell types explains many biological features of the disease, including its cellular heterogeneity, mutational spectrum, spontaneous regression, and response to drugs that induce tumor cell differentiation. In this review, we provide evidence that supports the notion that arrested neural-crest-derived progenitor cells give rise to neuroblastoma and discuss how this concept could be exploited for clinical management of the disease.

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Neuroblastoma: When differentiation goes awry

Abstract

ASJC Scopus subject areas

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