Neurobiology of Tourette syndrome: Current status and need for further investigation

Research output: Contribution to journalArticle

Abstract

Tourette syndrome (TS) is a common, chronic neuropsychiatric disorder characterized by the presence of fluctuating motor and phonic tics. The typical age of onset is ~5-7 years, and the majority of children improve by their late teens or early adulthood. Affected individuals are at increased risk for the development of various comorbid conditions, such as obsessive- compulsive disorder, attention deficit hyperactivity disorder, school problems, depression, and anxiety. There is no cure for tics, and symptomatic therapy includes behavioral and pharmacological approaches. Evidence supports TS being an inherited disorder; however, the precise genetic abnormality remains unknown. Pathologic involvement of cortico-striatal-thalamo-cortical (CSTC) pathways is supported by neurophysiological, brain imaging, and postmortem studies, but results are often confounded by small numbers, age differences, severity of symptoms, comorbidity, use of pharmacotherapy, and other factors. The primary site of abnormality remains controversial. Although numerous neurotransmitters participate in the transmission of messages through CSTC circuits, a dopaminergic dysfunction is considered a leading candidate. Several animal models have been used to study behaviors similar to tics as well as to pursue potential pathophysiological deficits. TS is a complex disorder with features overlapping a variety of scientific fields. Despite description of this syndrome in the late 19th century, there remain numerous unanswered neurobiological questions.

Original languageEnglish (US)
Pages (from-to)12387-12395
Number of pages9
JournalJournal of Neuroscience
Volume31
Issue number35
DOIs
StatePublished - Aug 31 2011

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Tics
Tourette Syndrome
Neurobiology
Corpus Striatum
Obsessive-Compulsive Disorder
Attention Deficit Disorder with Hyperactivity
Age of Onset
Neuroimaging
Neurotransmitter Agents
Comorbidity
Anxiety
Animal Models
Pharmacology
Depression
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neurobiology of Tourette syndrome : Current status and need for further investigation. / Felling, Ryan; Singer, Harvey.

In: Journal of Neuroscience, Vol. 31, No. 35, 31.08.2011, p. 12387-12395.

Research output: Contribution to journalArticle

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