Neurobiological issues in Tourette syndrome

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42 Scopus citations


The Tourette syndrome (TS) represents an intriguing disorder that overlaps the clinical fields of neurology and psychiatry. Composed of a spectrum of familial, involuntary motor and vocal tics and co-morbid neuropsychological problems, this disorder has become a model for investigators interested in neurobehavioral research. Although the subject of numerous reports since Tourette's original description in 1885, over the past decade there has been a rapid expansion of knowledge pertaining to the phenomenology of tic syndromes and their associated problems, the role of genetic and environmental factors, and the underlying pathophysiology. The role of frontal-subcortical circuits, dopaminergic neurotransmission, and second messenger systems are highlighted. This report provides a framework for understanding current neurobiological issues in TS.

Original languageEnglish (US)
Pages (from-to)353-364
Number of pages12
JournalBrain and Development
Issue number5
StatePublished - 1994


  • Co-morbidity
  • Genetic
  • Neuroanatomy
  • Neurochemistry
  • Phenomenology
  • Tic
  • Tourette syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology


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