Neurobehavioural sequelae of cardiopulmonary bypass

Ola A. Selnes, Maura A. Goldsborough, Louis M. Borowicz, Guy M. McKhann

Research output: Contribution to journalArticle

Abstract

The development of coronary artery bypass grafting (CABG) and its effect on angina is the product of a series of technical and scientific advances. Despite these advances, however, adverse neurobehavioural outcomes continue to occur. Stroke is the most serious complication of CABG, but studies that have identified demographic and medical risk factors available before surgery are an important advance. Short-term cognitive deficits are common after CABG, but may not be specific to this procedure. However, deficits in some cognitive areas such as visuoconstruction persist over time, and may reflect parieto-occipital watershed area injury secondary to hypoperfusion or embolic factors. Risk factors for cognitive decline may be time dependent, with short-term studies identifying factors that differ from those of long-term studies. Patients with depression before surgery are likely to have persistent depression afterwards. However, depression does not account for the cognitive decline after CABG. Since CABG is increasingly done in older patients with more comorbidity, the challenge is to identify patients at risk of adverse neurocognitive outcomes and to protect them by modification of the surgical procedure or by effective medical therapy.

Original languageEnglish (US)
Pages (from-to)1601-1606
Number of pages6
JournalThe Lancet
Volume353
Issue number9164
DOIs
StatePublished - May 8 1999

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Cardiopulmonary Bypass
Coronary Artery Bypass
Depression
Comorbidity
Stroke
Demography
Wounds and Injuries
Cognitive Dysfunction
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Selnes, O. A., Goldsborough, M. A., Borowicz, L. M., & McKhann, G. M. (1999). Neurobehavioural sequelae of cardiopulmonary bypass. The Lancet, 353(9164), 1601-1606. https://doi.org/10.1016/S0140-6736(98)07576-X

Neurobehavioural sequelae of cardiopulmonary bypass. / Selnes, Ola A.; Goldsborough, Maura A.; Borowicz, Louis M.; McKhann, Guy M.

In: The Lancet, Vol. 353, No. 9164, 08.05.1999, p. 1601-1606.

Research output: Contribution to journalArticle

Selnes, OA, Goldsborough, MA, Borowicz, LM & McKhann, GM 1999, 'Neurobehavioural sequelae of cardiopulmonary bypass', The Lancet, vol. 353, no. 9164, pp. 1601-1606. https://doi.org/10.1016/S0140-6736(98)07576-X
Selnes OA, Goldsborough MA, Borowicz LM, McKhann GM. Neurobehavioural sequelae of cardiopulmonary bypass. The Lancet. 1999 May 8;353(9164):1601-1606. https://doi.org/10.1016/S0140-6736(98)07576-X
Selnes, Ola A. ; Goldsborough, Maura A. ; Borowicz, Louis M. ; McKhann, Guy M. / Neurobehavioural sequelae of cardiopulmonary bypass. In: The Lancet. 1999 ; Vol. 353, No. 9164. pp. 1601-1606.
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