Neurobehavioral outcomes in children after out-of-hospital cardiac arrest

Beth S. Slomine, Faye S. Silverstein, James R. Christensen, Richard Holubkov, Kent Page, J. Michael Dean, Frank W. Moler

Research output: Contribution to journalArticle

Abstract

Objective: This study examined 12-month neurobehavioral outcomes in children who survived out-of-hospital cardiac arrest (OH-CA), were comatose after resuscitation, and were enrolled in a clinical trial to evaluate targeted temperature management to hypothermia (33.0°C) or normothermia (36.8°C) (Therapeutic Hypothermia after Pediatric Cardiac Arrest, Out-of-Hopsital [THAPCA-OH]; NCT00878644). Methods: Baseline functioning was assessed by caregiver responses on the Vineland Adaptive Behavior Scales-Second Edition (VABS-II) soon after OH-CA (based on functioning before OH-CA); children with broadly normal baseline functioning (VABS-II ≥70) were included in the THAPCA-OH primary outcome. VABS-II was completed again 12 months later. Then, face-to-face cognitive evaluations were completed. Analyses evaluated changes in VABS-II composite, domain, and subdomain scores and cognitive functioning at follow-up. Results: Ninety-six of 295 enrolled children were alive at 12 months; 87 of 96 had broadly normal baseline functioning (VABS-II ≥70). Follow-up was obtained on 85/87. Forty-two of 85 had VABS-II ≥70 at 12 months. VABS-II composite, domain, and subdomain scores declined significantly between baseline and 12-month follow-up (P

Original languageEnglish (US)
JournalPediatrics
Volume137
Issue number4
DOIs
StatePublished - Apr 1 2016

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Out-of-Hospital Cardiac Arrest
Psychological Adaptation
Induced Hypothermia
Heart Arrest
Pediatrics
Coma
Hypothermia
Resuscitation
Caregivers
Clinical Trials
Temperature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Slomine, B. S., Silverstein, F. S., Christensen, J. R., Holubkov, R., Page, K., Michael Dean, J., & Moler, F. W. (2016). Neurobehavioral outcomes in children after out-of-hospital cardiac arrest. Pediatrics, 137(4). DOI: 10.1542/peds.2015-3412

Neurobehavioral outcomes in children after out-of-hospital cardiac arrest. / Slomine, Beth S.; Silverstein, Faye S.; Christensen, James R.; Holubkov, Richard; Page, Kent; Michael Dean, J.; Moler, Frank W.

In: Pediatrics, Vol. 137, No. 4, 01.04.2016.

Research output: Contribution to journalArticle

Slomine, BS, Silverstein, FS, Christensen, JR, Holubkov, R, Page, K, Michael Dean, J & Moler, FW 2016, 'Neurobehavioral outcomes in children after out-of-hospital cardiac arrest' Pediatrics, vol 137, no. 4. DOI: 10.1542/peds.2015-3412
Slomine BS, Silverstein FS, Christensen JR, Holubkov R, Page K, Michael Dean J et al. Neurobehavioral outcomes in children after out-of-hospital cardiac arrest. Pediatrics. 2016 Apr 1;137(4). Available from, DOI: 10.1542/peds.2015-3412

Slomine, Beth S.; Silverstein, Faye S.; Christensen, James R.; Holubkov, Richard; Page, Kent; Michael Dean, J.; Moler, Frank W. / Neurobehavioral outcomes in children after out-of-hospital cardiac arrest.

In: Pediatrics, Vol. 137, No. 4, 01.04.2016.

Research output: Contribution to journalArticle

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