Neuroanatomical correlates of depression in post traumatic brain injury: Preliminary results of a pilot study

Vani A Rao, Cynthia Munro, Paul B Rosenberg, Julianna Ward, Melaine Bertrand, Mahaveer Degoankar, Alena Horská, Dzung Pham, David Mark Yousem, Peter B Barker

Research output: Contribution to journalArticle


The authors present preliminary results from a pilot study on patterns of brain injury associated with incident major depression after traumatic brain injury (TBI). Brain metabolite ratios, regional brain volumes, and cognitive performance were compared between 10 subjects with incident major depression post-TBI and seven TBI patients without major depression. TBI-depressed participants performed poorly on tests of frontotemporal functioning, had lower choline/creatine and N-acetylaspartate/creatine ratios in the right basal ganglia and had lower regional brain volumes in the right frontal, left occipital, and temporal lobes. The results suggest a possible role of frontotemporal lobe and basal ganglia pathology in depression after TBI.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number2
StatePublished - Mar 2010


ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

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