TY - JOUR
T1 - Neuroanatomic and functional correlates of depressed mood
T2 - The Cardiovascular Health Study
AU - Sato, Reiko
AU - Bryan, Nick
AU - Fried, Linda P.
N1 - Funding Information:
The research reported on in this article was supported by contracts NO1-HC-85079-NO1-HC-85086 from the National Heart, Lung, and Blood Institute, and Georgetown Echo RC - HL 35129 JHU MRI RC-HL 15103.
PY - 1999/11/1
Y1 - 1999/11/1
N2 - Although a number of studies suggest an association between stroke and depression, few have examined the relation between magnetic resonance imaging (MRI)-identified lesions and depression among community-dwelling older adults. This cross-sectional study sought to assess the association between MRI infarcts in the basal ganglia and non-basal-ganglia areas, potential functional consequences of these lesions, and depressive symptomatology in 3,371 US men and women aged 65 years or older who participated in the Cardiovascular Health Study between 1992 and 1994. By using multiple linear regression models, the authors found that after adjustment for age, gender, and stroke history, Center for Epidemiologic Studies Depression Scale scores were independently associated with non-basal-ganglia lesions (p = 0.04) but were not independently associated with basal ganglia lesions (p = 0.11). When measures of physical disability and cognitive impairment were added to the models, these measures displaced MRI-identified infarcts in their association with depressive symptoms. In additional models, hemispheric location and size of the basal ganglia lesion were found to have no relation to depression levels. These results suggest that the functional consequences of cerebrovascular disease may be the causal pathway by which basal ganglia and non-basal-ganglia lesions are associated with depressive symptomatology.
AB - Although a number of studies suggest an association between stroke and depression, few have examined the relation between magnetic resonance imaging (MRI)-identified lesions and depression among community-dwelling older adults. This cross-sectional study sought to assess the association between MRI infarcts in the basal ganglia and non-basal-ganglia areas, potential functional consequences of these lesions, and depressive symptomatology in 3,371 US men and women aged 65 years or older who participated in the Cardiovascular Health Study between 1992 and 1994. By using multiple linear regression models, the authors found that after adjustment for age, gender, and stroke history, Center for Epidemiologic Studies Depression Scale scores were independently associated with non-basal-ganglia lesions (p = 0.04) but were not independently associated with basal ganglia lesions (p = 0.11). When measures of physical disability and cognitive impairment were added to the models, these measures displaced MRI-identified infarcts in their association with depressive symptoms. In additional models, hemispheric location and size of the basal ganglia lesion were found to have no relation to depression levels. These results suggest that the functional consequences of cerebrovascular disease may be the causal pathway by which basal ganglia and non-basal-ganglia lesions are associated with depressive symptomatology.
KW - Aged
KW - Cerebral infarction
KW - Cerebrovascular disorders
KW - Depression
KW - Magnetic resonance imaging
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U2 - 10.1093/oxfordjournals.aje.a010100
DO - 10.1093/oxfordjournals.aje.a010100
M3 - Article
C2 - 10547137
AN - SCOPUS:0033231246
SN - 0002-9262
VL - 150
SP - 919
EP - 929
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 9
ER -