Neuro-Behcet Disease and Ocular Inflammation: A Case Report and Literature Review

Shaivi A. Patel, Chinwewa Okeagu, Krystyna Jones, Ammar Chaudhry, Meghan K. Berkenstock

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To describe a case of panuveitis with occlusive vasculitis leading to the diagnosis of neuro-Behcet disease (NBD) and discuss the relationship between uveitis and NBD. Methods: Case report with a literature review of ocular inflammation in NBD. Results: A 26-year-old woman with a seven-month history of recurrent cerebral venous sinus thromboses (CVST) and right-sided hemiparalysis secondary to rhombencephalitis presented with bilateral panuveitis and occlusive retinal vasculitis. Systemic evaluations were negative for hypercoagulability and infection. Although HLA-51 negative, the diagnosis was consistent with NBD. Conclusion: NBD is a rare subset of BD with a limited number of studies and patients. However, uveitis is more common in adults with parenchymal disease; may predate the development of neurological symptoms. The most common locations of ocular inflammation were posterior and panuveitis. MRI/V of the brain can identify enhancing lesions in the rhombencephalon or CVST in patients with uveitis with neurological findings.

Original languageEnglish (US)
JournalOcular Immunology and Inflammation
DOIs
StateAccepted/In press - 2020

Keywords

  • cerebral venous sinus thrombosis
  • Neurobehcet disease
  • occlusive retinal vasculitis
  • rhombencephalitis
  • uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

Fingerprint Dive into the research topics of 'Neuro-Behcet Disease and Ocular Inflammation: A Case Report and Literature Review'. Together they form a unique fingerprint.

Cite this