TY - JOUR
T1 - Neural Tissue Motion Impacts Cerebrospinal Fluid Dynamics at the Cervical Medullary Junction
T2 - A Patient-Specific Moving-Boundary Computational Model
AU - Pahlavian, Soroush Heidari
AU - Loth, Francis
AU - Luciano, Mark
AU - Oshinski, John
AU - Martin, Bryn A.
N1 - Publisher Copyright:
© 2015, Biomedical Engineering Society.
PY - 2015/6/25
Y1 - 2015/6/25
N2 - Central nervous system (CNS) tissue motion of the brain occurs over 30 million cardiac cycles per year due to intracranial pressure differences caused by the pulsatile blood flow and cerebrospinal fluid (CSF) motion within the intracranial space. This motion has been found to be elevated in type 1 Chiari malformation. The impact of CNS tissue motion on CSF dynamics was assessed using a moving-boundary computational fluid dynamics (CFD) model of the cervical-medullary junction (CMJ). The cerebellar tonsils and spinal cord were modeled as rigid surfaces moving in the caudocranial direction over the cardiac cycle. The CFD boundary conditions were based on in vivo MR imaging of a 35-year old female Chiari malformation patient with ~150–300 µm motion of the cerebellar tonsils and spinal cord, respectively. Results showed that tissue motion increased CSF pressure dissociation across the CMJ and peak velocities up to 120 and 60%, respectively. Alterations in CSF dynamics were most pronounced near the CMJ and during peak tonsillar velocity. These results show a small CNS tissue motion at the CMJ can alter CSF dynamics for a portion of the cardiac cycle and demonstrate the utility of CFD modeling coupled with MR imaging to help understand CSF dynamics.
AB - Central nervous system (CNS) tissue motion of the brain occurs over 30 million cardiac cycles per year due to intracranial pressure differences caused by the pulsatile blood flow and cerebrospinal fluid (CSF) motion within the intracranial space. This motion has been found to be elevated in type 1 Chiari malformation. The impact of CNS tissue motion on CSF dynamics was assessed using a moving-boundary computational fluid dynamics (CFD) model of the cervical-medullary junction (CMJ). The cerebellar tonsils and spinal cord were modeled as rigid surfaces moving in the caudocranial direction over the cardiac cycle. The CFD boundary conditions were based on in vivo MR imaging of a 35-year old female Chiari malformation patient with ~150–300 µm motion of the cerebellar tonsils and spinal cord, respectively. Results showed that tissue motion increased CSF pressure dissociation across the CMJ and peak velocities up to 120 and 60%, respectively. Alterations in CSF dynamics were most pronounced near the CMJ and during peak tonsillar velocity. These results show a small CNS tissue motion at the CMJ can alter CSF dynamics for a portion of the cardiac cycle and demonstrate the utility of CFD modeling coupled with MR imaging to help understand CSF dynamics.
KW - Central nervous system
KW - Cerebrospinal fluid
KW - Computational fluid dynamics
KW - Moving boundary simulation
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U2 - 10.1007/s10439-015-1355-y
DO - 10.1007/s10439-015-1355-y
M3 - Article
C2 - 26108203
AN - SCOPUS:84945464273
SN - 0090-6964
VL - 43
SP - 2911
EP - 2923
JO - Annals of biomedical engineering
JF - Annals of biomedical engineering
IS - 12
ER -