Neural Tissue Motion Impacts Cerebrospinal Fluid Dynamics at the Cervical Medullary Junction

A Patient-Specific Moving-Boundary Computational Model

Soroush Heidari Pahlavian, Francis Loth, Mark Luciano, John Oshinski, Bryn A. Martin

Research output: Contribution to journalArticle

Abstract

Central nervous system (CNS) tissue motion of the brain occurs over 30 million cardiac cycles per year due to intracranial pressure differences caused by the pulsatile blood flow and cerebrospinal fluid (CSF) motion within the intracranial space. This motion has been found to be elevated in type 1 Chiari malformation. The impact of CNS tissue motion on CSF dynamics was assessed using a moving-boundary computational fluid dynamics (CFD) model of the cervical-medullary junction (CMJ). The cerebellar tonsils and spinal cord were modeled as rigid surfaces moving in the caudocranial direction over the cardiac cycle. The CFD boundary conditions were based on in vivo MR imaging of a 35-year old female Chiari malformation patient with ~150–300 µm motion of the cerebellar tonsils and spinal cord, respectively. Results showed that tissue motion increased CSF pressure dissociation across the CMJ and peak velocities up to 120 and 60%, respectively. Alterations in CSF dynamics were most pronounced near the CMJ and during peak tonsillar velocity. These results show a small CNS tissue motion at the CMJ can alter CSF dynamics for a portion of the cardiac cycle and demonstrate the utility of CFD modeling coupled with MR imaging to help understand CSF dynamics.

Original languageEnglish (US)
Pages (from-to)2911-2923
Number of pages13
JournalAnnals of Biomedical Engineering
Volume43
Issue number12
DOIs
StatePublished - Jun 25 2015
Externally publishedYes

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Cerebrospinal fluid
Fluid dynamics
Tissue
Neurology
Computational fluid dynamics
Imaging techniques
Dynamic models
Brain
Blood
Boundary conditions

Keywords

  • Central nervous system
  • Cerebrospinal fluid
  • Computational fluid dynamics
  • Moving boundary simulation

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Neural Tissue Motion Impacts Cerebrospinal Fluid Dynamics at the Cervical Medullary Junction : A Patient-Specific Moving-Boundary Computational Model. / Pahlavian, Soroush Heidari; Loth, Francis; Luciano, Mark; Oshinski, John; Martin, Bryn A.

In: Annals of Biomedical Engineering, Vol. 43, No. 12, 25.06.2015, p. 2911-2923.

Research output: Contribution to journalArticle

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