Neural substrates of decision making in adults with attention deficit hyperactivity disorder

Monique Ernst, Alane S. Kimes, Edythe D. London, John A. Matochik, Dana Eldreth, Satya Tata, Carlo Contoreggi, Michelle Leff, Karen I Bolla

Research output: Contribution to journalArticle

Abstract

Objective: The characteristics of attention deficit hyperactivity disorder (ADHD) include abnormalities in reward responsivity that may interfere with decision making. The study examined reward responsivity in ADHD by comparing the neural correlates of decision making in adults with childhood-onset ADHD and in healthy adults. Method: The neural correlates of performance on a decision-making task and a control task were compared in 10 adults with ADHD and 12 age-matched healthy volunteers by using [15O]H2O positron emission tomography. The decision-making task tested the ability to weigh short-term rewards against long-term losses. The control task matched all components of the decision-making task except for the decision-making process and related contingency. Results: The ventral and dorsolateral prefrontal cortex and the insula were activated during performance of the decision-making task in both the ADHD and healthy groups; however, activation in the ADHD group was less extended and did not involve other regions, such as anterior cingulate and hippocampus, that subserve emotion/memory processes. Direct comparison of data from the ADHD subjects and the healthy volunteers suggested that the healthy subjects engaged the hippocampal and insular regions more than did the ADHD subjects and that the ADHD subjects recruited the caudal part of the right anterior cingulate more than did the healthy subjects. Conclusions: The findings suggest that the neural circuits engaged during decision making differ in subjects with ADHD and healthy comparison subjects. This difference may explain observed deficits in motivated behaviors in ADHD. A better understanding of the nature of these deficits could ultimately be applied to refine treatment strategies for ADHD.

Original languageEnglish (US)
Pages (from-to)1061-1070
Number of pages10
JournalAmerican Journal of Psychiatry
Volume160
Issue number6
DOIs
StatePublished - Jun 2003
Externally publishedYes

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Attention Deficit Disorder with Hyperactivity
Decision Making
Healthy Volunteers
Reward
Gyrus Cinguli
Aptitude
Prefrontal Cortex
Positron-Emission Tomography
Hippocampus
Emotions

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Neural substrates of decision making in adults with attention deficit hyperactivity disorder. / Ernst, Monique; Kimes, Alane S.; London, Edythe D.; Matochik, John A.; Eldreth, Dana; Tata, Satya; Contoreggi, Carlo; Leff, Michelle; Bolla, Karen I.

In: American Journal of Psychiatry, Vol. 160, No. 6, 06.2003, p. 1061-1070.

Research output: Contribution to journalArticle

Ernst, M, Kimes, AS, London, ED, Matochik, JA, Eldreth, D, Tata, S, Contoreggi, C, Leff, M & Bolla, KI 2003, 'Neural substrates of decision making in adults with attention deficit hyperactivity disorder', American Journal of Psychiatry, vol. 160, no. 6, pp. 1061-1070. https://doi.org/10.1176/appi.ajp.160.6.1061
Ernst, Monique ; Kimes, Alane S. ; London, Edythe D. ; Matochik, John A. ; Eldreth, Dana ; Tata, Satya ; Contoreggi, Carlo ; Leff, Michelle ; Bolla, Karen I. / Neural substrates of decision making in adults with attention deficit hyperactivity disorder. In: American Journal of Psychiatry. 2003 ; Vol. 160, No. 6. pp. 1061-1070.
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