Neural signals in cortex and thalamus during brain injury from cardiac arrest in rats

Dandan Zhang, Young Seok Choi, Jai Madhok, Xiaofeng Jia, Matthew Koenig, Nitish Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Previous research has shown that a characteristic burst-suppression (BS) pattern appears in EEG during the early recovery period following cardiac arrest (CA). To study cortical and subcortical neural activity underlying BS, extracellular activity in the parietal cortex and the centromedian nucleus of the thalamus and extradural EEG were recorded in a rodent CA model. Preliminary results show that during the BS, the cortical firing rate is extraordinarily high, and that bursts in EEG correlate to dense spikes in cortical neurons. An unexpected and novel observation is that 1) thalamic activity reappears earlier than cortical activity following CA, and 2) the correlation coefficient of cortical and thalamic activity rises during BS period. These results will help elucidate the mechanism of brain recovery after CA injury.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages5946-5949
Number of pages4
ISBN (Print)9781424432967
DOIs
StatePublished - Jan 1 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Publication series

NameProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

    Fingerprint

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Zhang, D., Choi, Y. S., Madhok, J., Jia, X., Koenig, M., & Thakor, N. (2009). Neural signals in cortex and thalamus during brain injury from cardiac arrest in rats. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 5946-5949). [5334759] (Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009). IEEE Computer Society. https://doi.org/10.1109/IEMBS.2009.5334759