Neural prosthesis for motor function restoration in upper limb extremity

Sudip Nag; Kian Ann Ng; Rangarajan Jagadeesan; Swathi Sheshadri; Ignacio Delgado-Martinez; Silvia Bossi; Shih Cheng Yen; Nitish V. Thakor

doi:10.1109/BioCAS.2014.6981744

Neural prosthesis for motor function restoration in upper limb extremity

Sudip Nag, Kian Ann Ng, Rangarajan Jagadeesan, Swathi Sheshadri, Ignacio Delgado-Martinez, Silvia Bossi, Shih Cheng Yen, Nitish V. Thakor

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

7 Scopus citations

Abstract

Restoration of motor function in cases of peripheral nerve injury is a challenging problem. Although peripheral nerves do regenerate, the time required for peripheral nerves to regenerate often causes atrophy to occur in the muscles before they can be re-innervated. This paper presents a solution through proximal recording of nerve signals and distal muscle stimulation. A fully implantable hardware architecture is described that can be operated by means of inductive power and MICS band data transmission schemes. Preliminary experiments and validation studies are reported with non-human primates based on recordings in the median nerve, stimulation of hand muscles, and task decoding and classification. This approach shows promise in creating a neural prosthesis capable of restoring hand movements in patients with upper limb peripheral nerve injuries.

Original language	English (US)
Title of host publication	IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	388-391
Number of pages	4
ISBN (Electronic)	9781479923465
DOIs	https://doi.org/10.1109/BioCAS.2014.6981744
State	Published - Dec 9 2014
Event	10th IEEE Biomedical Circuits and Systems Conference, BioCAS 2014 - Lausanne, Switzerland Duration: Oct 22 2014 → Oct 24 2014

Publication series

Name	IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings

Other

Other	10th IEEE Biomedical Circuits and Systems Conference, BioCAS 2014
Country/Territory	Switzerland
City	Lausanne
Period	10/22/14 → 10/24/14

ASJC Scopus subject areas

Hardware and Architecture
Biomedical Engineering

Access to Document

10.1109/BioCAS.2014.6981744

Cite this

Nag, S., Ng, K. A., Jagadeesan, R., Sheshadri, S., Delgado-Martinez, I., Bossi, S., Yen, S. C., & Thakor, N. V. (2014). Neural prosthesis for motor function restoration in upper limb extremity. In IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings (pp. 388-391). Article 6981744 (IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BioCAS.2014.6981744

Neural prosthesis for motor function restoration in upper limb extremity. / Nag, Sudip; Ng, Kian Ann; Jagadeesan, Rangarajan et al.
IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2014. p. 388-391 6981744 (IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Nag, S, Ng, KA, Jagadeesan, R, Sheshadri, S, Delgado-Martinez, I, Bossi, S, Yen, SC & Thakor, NV 2014, Neural prosthesis for motor function restoration in upper limb extremity. in IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings., 6981744, IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings, Institute of Electrical and Electronics Engineers Inc., pp. 388-391, 10th IEEE Biomedical Circuits and Systems Conference, BioCAS 2014, Lausanne, Switzerland, 10/22/14. https://doi.org/10.1109/BioCAS.2014.6981744

Nag S, Ng KA, Jagadeesan R, Sheshadri S, Delgado-Martinez I, Bossi S et al. Neural prosthesis for motor function restoration in upper limb extremity. In IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2014. p. 388-391. 6981744. (IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings). doi: 10.1109/BioCAS.2014.6981744

Nag, Sudip ; Ng, Kian Ann ; Jagadeesan, Rangarajan et al. / Neural prosthesis for motor function restoration in upper limb extremity. IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2014. pp. 388-391 (IEEE 2014 Biomedical Circuits and Systems Conference, BioCAS 2014 - Proceedings).

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abstract = "Restoration of motor function in cases of peripheral nerve injury is a challenging problem. Although peripheral nerves do regenerate, the time required for peripheral nerves to regenerate often causes atrophy to occur in the muscles before they can be re-innervated. This paper presents a solution through proximal recording of nerve signals and distal muscle stimulation. A fully implantable hardware architecture is described that can be operated by means of inductive power and MICS band data transmission schemes. Preliminary experiments and validation studies are reported with non-human primates based on recordings in the median nerve, stimulation of hand muscles, and task decoding and classification. This approach shows promise in creating a neural prosthesis capable of restoring hand movements in patients with upper limb peripheral nerve injuries.",

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AB - Restoration of motor function in cases of peripheral nerve injury is a challenging problem. Although peripheral nerves do regenerate, the time required for peripheral nerves to regenerate often causes atrophy to occur in the muscles before they can be re-innervated. This paper presents a solution through proximal recording of nerve signals and distal muscle stimulation. A fully implantable hardware architecture is described that can be operated by means of inductive power and MICS band data transmission schemes. Preliminary experiments and validation studies are reported with non-human primates based on recordings in the median nerve, stimulation of hand muscles, and task decoding and classification. This approach shows promise in creating a neural prosthesis capable of restoring hand movements in patients with upper limb peripheral nerve injuries.

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Neural prosthesis for motor function restoration in upper limb extremity

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