Neural networks essential for naming and word comprehension

Melissa Newhart, Lynda Ken, Jonathan T. Kleinman, Jennifer Heidler-Gary, Argye E. Hillis

Research output: Contribution to journalArticlepeer-review


Lesion/deficit association studies of aphasia commonly focus on one brain region as primarily responsible for a particular language deficit. However, functional imaging and some lesion studies indicate that multiple brain regions are likely necessary for any language task. We tested 156 acute stroke patients on basic language tasks (naming and spoken and written word comprehension) and magnetic resonance diffusion and perfusion imaging to determine the relative contributions of various brain regions to each task. Multivariate linear regression analysis indicated that the error rate on each task was best predicted by dysfunction in several perisylvian regions, with both common and distinct regions for the 3 tasks.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalCognitive and Behavioral Neurology
Issue number1
StatePublished - Mar 2007


  • Acute stroke
  • Anomia
  • Aphasia
  • Magnetic resonance perfusion imaging

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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