Abstract
Microelectronic technology has been used to construct passive, multisite microprobes for investigating the electrical activity of neurons in live brain tissue. The probes are built on a thin molybdenum support, with gold electrodes sandwiched between two polyimide dielectric layers. Windows in the top insulating layer expose the electrode sites and bonding pads. Microprobes with different numbers of sites have been constructed for use in various experimental situations. A critical consideration is the useful lifetime of the probes under in vivo experimental conditions. Probes have survived immersion in saline solution for more than 750 hours before site impedance degradation indicated failure. A four-site probe has been used to observe neural activity in the dorsal columns of anesthetized rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-165 |
| Number of pages | 7 |
| Journal | Johns Hopkins APL Technical Digest (Applied Physics Laboratory) |
| Volume | 12 |
| Issue number | 2 |
| State | Published - Apr 1 1991 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Engineering
- General Physics and Astronomy