Neural microprobes for multisite recording

Norman A. Blum, Bliss G. Carkhuff, Harry K. Charles, Richard L. Edwards, A. Shaun Francomacaro, Richard Meyer

Research output: Contribution to journalArticle

Abstract

Microelectronic technology has been used to construct passive, multisite microprobes for investigating the electrical activity of neurons in live brain tissue. The probes are built on a thin molybdenum support, with gold electrodes sandwiched between two polyimide dielectric layers. Windows in the top insulating layer expose the electrode sites and bonding pads. Microprobes with different numbers of sites have been constructed for use in various experimental situations. A critical consideration is the useful lifetime of the probes under in vivo experimental conditions. Probes have survived immersion in saline solution for more than 750 hours before site impedance degradation indicated failure. A four-site probe has been used to observe neural activity in the dorsal columns of anesthetized rats.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalJohns Hopkins APL Technical Digest (Applied Physics Laboratory)
Volume12
Issue number2
StatePublished - Apr 1991
Externally publishedYes

Fingerprint

recording
probes
Electrodes
electrodes
neurons
polyimides
Polyimides
microelectronics
Microelectronics
submerging
Molybdenum
rats
Neurons
molybdenum
brain
Rats
Brain
Gold
impedance
Tissue

ASJC Scopus subject areas

  • General
  • Physics and Astronomy (miscellaneous)

Cite this

Blum, N. A., Carkhuff, B. G., Charles, H. K., Edwards, R. L., Francomacaro, A. S., & Meyer, R. (1991). Neural microprobes for multisite recording. Johns Hopkins APL Technical Digest (Applied Physics Laboratory), 12(2), 159-165.

Neural microprobes for multisite recording. / Blum, Norman A.; Carkhuff, Bliss G.; Charles, Harry K.; Edwards, Richard L.; Francomacaro, A. Shaun; Meyer, Richard.

In: Johns Hopkins APL Technical Digest (Applied Physics Laboratory), Vol. 12, No. 2, 04.1991, p. 159-165.

Research output: Contribution to journalArticle

Blum, NA, Carkhuff, BG, Charles, HK, Edwards, RL, Francomacaro, AS & Meyer, R 1991, 'Neural microprobes for multisite recording', Johns Hopkins APL Technical Digest (Applied Physics Laboratory), vol. 12, no. 2, pp. 159-165.
Blum NA, Carkhuff BG, Charles HK, Edwards RL, Francomacaro AS, Meyer R. Neural microprobes for multisite recording. Johns Hopkins APL Technical Digest (Applied Physics Laboratory). 1991 Apr;12(2):159-165.
Blum, Norman A. ; Carkhuff, Bliss G. ; Charles, Harry K. ; Edwards, Richard L. ; Francomacaro, A. Shaun ; Meyer, Richard. / Neural microprobes for multisite recording. In: Johns Hopkins APL Technical Digest (Applied Physics Laboratory). 1991 ; Vol. 12, No. 2. pp. 159-165.
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