Neural mechanisms of abnormal sensations after nerve injury

Richard Meyer, Gabriele Monika Koschorke, Donna B. Tillman, James N Campbell

Research output: Contribution to journalArticle

Abstract

Patients with injured nerves often report that tapping at the site of injury produces tingling sensations in the original territory of the nerve. Recordings from single nerve fibers in primates indicate that a sensitivity to mechanical stimuli develops after a nerve injury at regenerating nerve fibers; this sensitivity likely accounts for the sensations reported by patients. Vibratory stimuli were applied to regenerating fibers to determine their frequency-response properties. Fibers were grouped into three types, based on their responses: (1) fibers most sensitive to frequencies less than 5 Hz; (2) fibers most sensitive to middle frequencies (10-50 Hz); and (3) fibers most sensitive to frequencies greater than 100 Hz. These responses are similar to those of normal mechanoreceptors in the skin responsible for touch sensation. On the basis of these results, we propose a mechanism that explains the development of mechanosensitivity in injured nerve fibers.

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalJohns Hopkins APL Technical Digest (Applied Physics Laboratory)
Volume12
Issue number2
StatePublished - Apr 1991

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nerves
nerve fibers
fibers
Fibers
stimuli
mechanoreceptors
primates
touch
sensitivity
frequency response
recording
Frequency response
Skin

ASJC Scopus subject areas

  • General
  • Physics and Astronomy (miscellaneous)

Cite this

Neural mechanisms of abnormal sensations after nerve injury. / Meyer, Richard; Koschorke, Gabriele Monika; Tillman, Donna B.; Campbell, James N.

In: Johns Hopkins APL Technical Digest (Applied Physics Laboratory), Vol. 12, No. 2, 04.1991, p. 129-136.

Research output: Contribution to journalArticle

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