Neural correlates of strategic processes underlying episodic memory in women with major depression: A15O-PET study

William E. Ottowitz, Thilo Deckersbach, Cary R. Savage, Martin A. Lindquist, Darin D. Dougherty

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the functional integrity of brain regions underlying strategic mnemonic processing in patients with major depressive disorder, the authors administered a modified version of the California Verbal Learning Test to depressed patients during presentation of lists of unrelated words and, conversely, during presentation of lists of related words with and without orientation regarding the relatedness of the words (eight healthy females, IQ=122, and eight depressed females, IQ=107). Brain function evaluated across all three conditions showed that patients with major depressive disorder revealed activation of the right anterior cingulate cortex, left ventrolateral prefrontal cortex, both hippocampi, and the left orbitofrontal cortex. Further analysis showed that patients with major depressive disorder had greater activation of the right anterior cingulate cortex during semantic organization and the right ventrolateral prefrontal cortex during strategy initiation.

Original languageEnglish (US)
Pages (from-to)218-230
Number of pages13
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume22
Issue number2
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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