Neural correlates of high and craving during cocaine self-administration using BOLD fMRI

Robert C. Risinger, Betty Jo Salmeron, Thomas J. Ross, Shelley L. Amen, Michael Sanfilipo, Raymond G. Hoffmann, Alan S. Bloom, Hugh Garavan, Elliot A. Stein

Research output: Contribution to journalArticle

Abstract

Modern theories of drug dependence hold the hedonic effects of drug-taking central to understanding the motivation for compulsive drug use. Previous neuroimaging studies have begun to identify brain regions associated with acute drug effects after passive delivery. In this study, a more naturalistic model of cocaine self-administration (SA) was employed in order to identify those sites associated with drug-induced high and craving as measures of reward and motivation. Non-treatment seeking cocaine-dependent subjects chose both when and how often i.v. cocaine administration occurred within a medically supervised SA procedure. Both functional magnetic resonance imaging (fMRI) data and real-time behavioral ratings were acquired during the 1-h SA period. Drug-induced HIGH was found to correlate negatively with activity in limbic, paralimbic, and mesocortical regions including the nucleus accumbens (NAc), inferior frontal/orbitofrontal gyrus (OFC), and anterior cingulate (AC), while CRAVING correlated positively with activity in these regions. This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system.

Original languageEnglish (US)
Pages (from-to)1097-1108
Number of pages12
JournalNeuroImage
Volume26
Issue number4
DOIs
StatePublished - Jul 15 2005
Externally publishedYes

Fingerprint

Self Administration
Cocaine
Magnetic Resonance Imaging
Pharmaceutical Preparations
Prefrontal Cortex
Reward
Motivation
Pleasure
Gyrus Cinguli
Nucleus Accumbens
Neuroimaging
Substance-Related Disorders
Craving
Brain

Keywords

  • Cocaine
  • Drug abuse
  • Functional magnetic resonance imaging
  • Neurobiology
  • Reinforcement
  • Self-administration

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Risinger, R. C., Salmeron, B. J., Ross, T. J., Amen, S. L., Sanfilipo, M., Hoffmann, R. G., ... Stein, E. A. (2005). Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. NeuroImage, 26(4), 1097-1108. https://doi.org/10.1016/j.neuroimage.2005.03.030

Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. / Risinger, Robert C.; Salmeron, Betty Jo; Ross, Thomas J.; Amen, Shelley L.; Sanfilipo, Michael; Hoffmann, Raymond G.; Bloom, Alan S.; Garavan, Hugh; Stein, Elliot A.

In: NeuroImage, Vol. 26, No. 4, 15.07.2005, p. 1097-1108.

Research output: Contribution to journalArticle

Risinger, RC, Salmeron, BJ, Ross, TJ, Amen, SL, Sanfilipo, M, Hoffmann, RG, Bloom, AS, Garavan, H & Stein, EA 2005, 'Neural correlates of high and craving during cocaine self-administration using BOLD fMRI', NeuroImage, vol. 26, no. 4, pp. 1097-1108. https://doi.org/10.1016/j.neuroimage.2005.03.030
Risinger RC, Salmeron BJ, Ross TJ, Amen SL, Sanfilipo M, Hoffmann RG et al. Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. NeuroImage. 2005 Jul 15;26(4):1097-1108. https://doi.org/10.1016/j.neuroimage.2005.03.030
Risinger, Robert C. ; Salmeron, Betty Jo ; Ross, Thomas J. ; Amen, Shelley L. ; Sanfilipo, Michael ; Hoffmann, Raymond G. ; Bloom, Alan S. ; Garavan, Hugh ; Stein, Elliot A. / Neural correlates of high and craving during cocaine self-administration using BOLD fMRI. In: NeuroImage. 2005 ; Vol. 26, No. 4. pp. 1097-1108.
@article{480ff1f1c6d14c86874908dc627311fd,
title = "Neural correlates of high and craving during cocaine self-administration using BOLD fMRI",
abstract = "Modern theories of drug dependence hold the hedonic effects of drug-taking central to understanding the motivation for compulsive drug use. Previous neuroimaging studies have begun to identify brain regions associated with acute drug effects after passive delivery. In this study, a more naturalistic model of cocaine self-administration (SA) was employed in order to identify those sites associated with drug-induced high and craving as measures of reward and motivation. Non-treatment seeking cocaine-dependent subjects chose both when and how often i.v. cocaine administration occurred within a medically supervised SA procedure. Both functional magnetic resonance imaging (fMRI) data and real-time behavioral ratings were acquired during the 1-h SA period. Drug-induced HIGH was found to correlate negatively with activity in limbic, paralimbic, and mesocortical regions including the nucleus accumbens (NAc), inferior frontal/orbitofrontal gyrus (OFC), and anterior cingulate (AC), while CRAVING correlated positively with activity in these regions. This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system.",
keywords = "Cocaine, Drug abuse, Functional magnetic resonance imaging, Neurobiology, Reinforcement, Self-administration",
author = "Risinger, {Robert C.} and Salmeron, {Betty Jo} and Ross, {Thomas J.} and Amen, {Shelley L.} and Michael Sanfilipo and Hoffmann, {Raymond G.} and Bloom, {Alan S.} and Hugh Garavan and Stein, {Elliot A.}",
year = "2005",
month = "7",
day = "15",
doi = "10.1016/j.neuroimage.2005.03.030",
language = "English (US)",
volume = "26",
pages = "1097--1108",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Neural correlates of high and craving during cocaine self-administration using BOLD fMRI

AU - Risinger, Robert C.

AU - Salmeron, Betty Jo

AU - Ross, Thomas J.

AU - Amen, Shelley L.

AU - Sanfilipo, Michael

AU - Hoffmann, Raymond G.

AU - Bloom, Alan S.

AU - Garavan, Hugh

AU - Stein, Elliot A.

PY - 2005/7/15

Y1 - 2005/7/15

N2 - Modern theories of drug dependence hold the hedonic effects of drug-taking central to understanding the motivation for compulsive drug use. Previous neuroimaging studies have begun to identify brain regions associated with acute drug effects after passive delivery. In this study, a more naturalistic model of cocaine self-administration (SA) was employed in order to identify those sites associated with drug-induced high and craving as measures of reward and motivation. Non-treatment seeking cocaine-dependent subjects chose both when and how often i.v. cocaine administration occurred within a medically supervised SA procedure. Both functional magnetic resonance imaging (fMRI) data and real-time behavioral ratings were acquired during the 1-h SA period. Drug-induced HIGH was found to correlate negatively with activity in limbic, paralimbic, and mesocortical regions including the nucleus accumbens (NAc), inferior frontal/orbitofrontal gyrus (OFC), and anterior cingulate (AC), while CRAVING correlated positively with activity in these regions. This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system.

AB - Modern theories of drug dependence hold the hedonic effects of drug-taking central to understanding the motivation for compulsive drug use. Previous neuroimaging studies have begun to identify brain regions associated with acute drug effects after passive delivery. In this study, a more naturalistic model of cocaine self-administration (SA) was employed in order to identify those sites associated with drug-induced high and craving as measures of reward and motivation. Non-treatment seeking cocaine-dependent subjects chose both when and how often i.v. cocaine administration occurred within a medically supervised SA procedure. Both functional magnetic resonance imaging (fMRI) data and real-time behavioral ratings were acquired during the 1-h SA period. Drug-induced HIGH was found to correlate negatively with activity in limbic, paralimbic, and mesocortical regions including the nucleus accumbens (NAc), inferior frontal/orbitofrontal gyrus (OFC), and anterior cingulate (AC), while CRAVING correlated positively with activity in these regions. This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system.

KW - Cocaine

KW - Drug abuse

KW - Functional magnetic resonance imaging

KW - Neurobiology

KW - Reinforcement

KW - Self-administration

UR - http://www.scopus.com/inward/record.url?scp=20444405004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20444405004&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2005.03.030

DO - 10.1016/j.neuroimage.2005.03.030

M3 - Article

C2 - 15886020

AN - SCOPUS:20444405004

VL - 26

SP - 1097

EP - 1108

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

IS - 4

ER -