Neural correlates of cognitive control deficits in children with reading disorder

Amy E. Margolis, David Pagliaccio, Katie Davis, Lauren Thomas, Sarah M. Banker, Marilyn Cyr, Rachel Marsh

Research output: Contribution to journalArticle

Abstract

Reading disorder (RD) is characterized by deficient phonological processing, but children with RD also have cognitive control deficits, the neural correlates of which are not fully understood. We used fMRI to assess neural activity during the resolution of cognitive conflict on the Simon Spatial Incompatibility task and patterns of resting-state functional connectivity (RSFC) from task control (TC) regions in 7–12-year-old children with RD compared to their typically developing (TD) peers. Relative to TD children (n = 17), those with RD (n = 16) over-engaged a right superior/medial frontal cluster during the resolution of conflict (p =.05). Relative to TD children (n = 18), those with RD (n = 17) also showed reduced RSFC (voxel-wise p <.001; cluster-size p <.05, FDR corrected) from cingulo-opercular seeds to left hemisphere fronto-parietal and temporo-parietal reading-related regions, perhaps reflecting reduced organization of TC circuits and reduced integration with reading-related regions. Children with RD additionally showed reduced RSFC between fronto-parietal and default mode network regions. Follow-up analyses in a subset of children with both useable task and resting state data (RD = 13; TD = 17) revealed that greater conflict-related activation of the right frontal Simon task ROI associated with better word-reading, perhaps suggesting a compensatory role for this over-engagement. Connectivity from fronto-parietal seeds significantly associated with Simon task performance and word-reading accuracy in RD children. These findings suggest that altered functioning and connectivity of control circuits may contribute to cognitive control deficits in children with RD. Future studies should assess the utility of adding cognitive control training to reading remediation programs.

Original languageEnglish (US)
JournalBrain Imaging and Behavior
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Dyslexia
Reading
Negotiating
Seeds
Task Performance and Analysis
Magnetic Resonance Imaging

Keywords

  • Cognitive control
  • Conflict resolution
  • Dyslexia
  • fMRI
  • Reading disorder

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Neural correlates of cognitive control deficits in children with reading disorder. / Margolis, Amy E.; Pagliaccio, David; Davis, Katie; Thomas, Lauren; Banker, Sarah M.; Cyr, Marilyn; Marsh, Rachel.

In: Brain Imaging and Behavior, 01.01.2019.

Research output: Contribution to journalArticle

Margolis, Amy E. ; Pagliaccio, David ; Davis, Katie ; Thomas, Lauren ; Banker, Sarah M. ; Cyr, Marilyn ; Marsh, Rachel. / Neural correlates of cognitive control deficits in children with reading disorder. In: Brain Imaging and Behavior. 2019.
@article{ae86c2ed645644a2a03ed91733221aa0,
title = "Neural correlates of cognitive control deficits in children with reading disorder",
abstract = "Reading disorder (RD) is characterized by deficient phonological processing, but children with RD also have cognitive control deficits, the neural correlates of which are not fully understood. We used fMRI to assess neural activity during the resolution of cognitive conflict on the Simon Spatial Incompatibility task and patterns of resting-state functional connectivity (RSFC) from task control (TC) regions in 7–12-year-old children with RD compared to their typically developing (TD) peers. Relative to TD children (n = 17), those with RD (n = 16) over-engaged a right superior/medial frontal cluster during the resolution of conflict (p =.05). Relative to TD children (n = 18), those with RD (n = 17) also showed reduced RSFC (voxel-wise p <.001; cluster-size p <.05, FDR corrected) from cingulo-opercular seeds to left hemisphere fronto-parietal and temporo-parietal reading-related regions, perhaps reflecting reduced organization of TC circuits and reduced integration with reading-related regions. Children with RD additionally showed reduced RSFC between fronto-parietal and default mode network regions. Follow-up analyses in a subset of children with both useable task and resting state data (RD = 13; TD = 17) revealed that greater conflict-related activation of the right frontal Simon task ROI associated with better word-reading, perhaps suggesting a compensatory role for this over-engagement. Connectivity from fronto-parietal seeds significantly associated with Simon task performance and word-reading accuracy in RD children. These findings suggest that altered functioning and connectivity of control circuits may contribute to cognitive control deficits in children with RD. Future studies should assess the utility of adding cognitive control training to reading remediation programs.",
keywords = "Cognitive control, Conflict resolution, Dyslexia, fMRI, Reading disorder",
author = "Margolis, {Amy E.} and David Pagliaccio and Katie Davis and Lauren Thomas and Banker, {Sarah M.} and Marilyn Cyr and Rachel Marsh",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s11682-019-00083-x",
language = "English (US)",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",

}

TY - JOUR

T1 - Neural correlates of cognitive control deficits in children with reading disorder

AU - Margolis, Amy E.

AU - Pagliaccio, David

AU - Davis, Katie

AU - Thomas, Lauren

AU - Banker, Sarah M.

AU - Cyr, Marilyn

AU - Marsh, Rachel

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Reading disorder (RD) is characterized by deficient phonological processing, but children with RD also have cognitive control deficits, the neural correlates of which are not fully understood. We used fMRI to assess neural activity during the resolution of cognitive conflict on the Simon Spatial Incompatibility task and patterns of resting-state functional connectivity (RSFC) from task control (TC) regions in 7–12-year-old children with RD compared to their typically developing (TD) peers. Relative to TD children (n = 17), those with RD (n = 16) over-engaged a right superior/medial frontal cluster during the resolution of conflict (p =.05). Relative to TD children (n = 18), those with RD (n = 17) also showed reduced RSFC (voxel-wise p <.001; cluster-size p <.05, FDR corrected) from cingulo-opercular seeds to left hemisphere fronto-parietal and temporo-parietal reading-related regions, perhaps reflecting reduced organization of TC circuits and reduced integration with reading-related regions. Children with RD additionally showed reduced RSFC between fronto-parietal and default mode network regions. Follow-up analyses in a subset of children with both useable task and resting state data (RD = 13; TD = 17) revealed that greater conflict-related activation of the right frontal Simon task ROI associated with better word-reading, perhaps suggesting a compensatory role for this over-engagement. Connectivity from fronto-parietal seeds significantly associated with Simon task performance and word-reading accuracy in RD children. These findings suggest that altered functioning and connectivity of control circuits may contribute to cognitive control deficits in children with RD. Future studies should assess the utility of adding cognitive control training to reading remediation programs.

AB - Reading disorder (RD) is characterized by deficient phonological processing, but children with RD also have cognitive control deficits, the neural correlates of which are not fully understood. We used fMRI to assess neural activity during the resolution of cognitive conflict on the Simon Spatial Incompatibility task and patterns of resting-state functional connectivity (RSFC) from task control (TC) regions in 7–12-year-old children with RD compared to their typically developing (TD) peers. Relative to TD children (n = 17), those with RD (n = 16) over-engaged a right superior/medial frontal cluster during the resolution of conflict (p =.05). Relative to TD children (n = 18), those with RD (n = 17) also showed reduced RSFC (voxel-wise p <.001; cluster-size p <.05, FDR corrected) from cingulo-opercular seeds to left hemisphere fronto-parietal and temporo-parietal reading-related regions, perhaps reflecting reduced organization of TC circuits and reduced integration with reading-related regions. Children with RD additionally showed reduced RSFC between fronto-parietal and default mode network regions. Follow-up analyses in a subset of children with both useable task and resting state data (RD = 13; TD = 17) revealed that greater conflict-related activation of the right frontal Simon task ROI associated with better word-reading, perhaps suggesting a compensatory role for this over-engagement. Connectivity from fronto-parietal seeds significantly associated with Simon task performance and word-reading accuracy in RD children. These findings suggest that altered functioning and connectivity of control circuits may contribute to cognitive control deficits in children with RD. Future studies should assess the utility of adding cognitive control training to reading remediation programs.

KW - Cognitive control

KW - Conflict resolution

KW - Dyslexia

KW - fMRI

KW - Reading disorder

UR - http://www.scopus.com/inward/record.url?scp=85072193043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072193043&partnerID=8YFLogxK

U2 - 10.1007/s11682-019-00083-x

DO - 10.1007/s11682-019-00083-x

M3 - Article

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

ER -