TY - JOUR
T1 - Neural circuit mechanisms encoding motivational states in Drosophila
AU - Lee, Sang Soo
AU - Wu, Mark N.
N1 - Funding Information:
We thank the reviewers for helpful feedback and apologize to investigators in this field, whose work we were unable to cover due to space limitations. This work was supported by N.I.H. grant R01NS100792 (M.N.W.).
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/10
Y1 - 2020/10
N2 - Animals engage in motivated behaviors, such as feeding and mating behaviors, to ensure their own survival and the survival of their species. However, the neural circuits mediating the generation and persistence of these motivational drives remain poorly understood. Here we review recent studies on the circuit mechanisms underlying motivational states in Drosophila, with a focus on feeding, courtship, and aggression. These studies shed light on the molecular and cellular mechanisms by, which key drive neurons receive relevant input signals, integrate information, and decide on a specific behavioral output. We also discuss conceptual models for integrating these circuit mechanisms, distinguishing between those for homeostatically-regulated versus non-homeostatically-regulated motivated behaviors. We suggest that the ability to trigger persistence of a motivated behavior may be a feature of integrator or apex/command neurons.
AB - Animals engage in motivated behaviors, such as feeding and mating behaviors, to ensure their own survival and the survival of their species. However, the neural circuits mediating the generation and persistence of these motivational drives remain poorly understood. Here we review recent studies on the circuit mechanisms underlying motivational states in Drosophila, with a focus on feeding, courtship, and aggression. These studies shed light on the molecular and cellular mechanisms by, which key drive neurons receive relevant input signals, integrate information, and decide on a specific behavioral output. We also discuss conceptual models for integrating these circuit mechanisms, distinguishing between those for homeostatically-regulated versus non-homeostatically-regulated motivated behaviors. We suggest that the ability to trigger persistence of a motivated behavior may be a feature of integrator or apex/command neurons.
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U2 - 10.1016/j.conb.2020.05.002
DO - 10.1016/j.conb.2020.05.002
M3 - Review article
C2 - 32563845
AN - SCOPUS:85086502448
SN - 0959-4388
VL - 64
SP - 135
EP - 142
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -