Neural bases of orthographic long-term memory and working memory in dysgraphia

Brenda C Rapp, Jeremy Purcell, Argye Hillis-Trupe, Rita Capasso, Gabriele Miceli

Research output: Contribution to journalArticle

Abstract

Spelling a word involves the retrieval of information about the word's letters and their order from long-term memory as well as the maintenance and processing of this information by working memory in preparation for serial production by the motor system. While it is known that brain lesions may selectively affect orthographic long-term memory and working memory processes, relatively little is known about the neurotopographic distribution of the substrates that support these cognitive processes, or the lesions that give rise to the distinct forms of dysgraphia that affect these cognitive processes. To examine these issues, this study uses a voxel-based mapping approach to analyse the lesion distribution of 27 individuals with dysgraphia subsequent to stroke, who were identified on the basis of their behavioural profiles alone, as suffering from deficits only affecting either orthographic long-term or working memory, as well as six other individuals with deficits affecting both sets of processes. The findings provide, for the first time, clear evidence of substrates that selectively support orthographic long-term and working memory processes, with orthographic long-term memory deficits centred in either the left posterior inferior frontal region or left ventral temporal cortex, and orthographic working memory deficits primarily arising from lesions of the left parietal cortex centred on the intraparietal sulcus. These findings also contribute to our understanding of the relationship between the neural instantiation of written language processes and spoken language, working memory and other cognitive skills.

Original languageEnglish (US)
Pages (from-to)588-604
Number of pages17
JournalBrain
Volume139
Issue number2
DOIs
StatePublished - Dec 21 2015

Fingerprint

Agraphia
Long-Term Memory
Short-Term Memory
Parietal Lobe
Memory Disorders
Language
Information Storage and Retrieval
Temporal Lobe
Automatic Data Processing
Stroke
Maintenance
Brain

Keywords

  • dysgraphia
  • orthography
  • spelling
  • working memory

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Neural bases of orthographic long-term memory and working memory in dysgraphia. / Rapp, Brenda C; Purcell, Jeremy; Hillis-Trupe, Argye; Capasso, Rita; Miceli, Gabriele.

In: Brain, Vol. 139, No. 2, 21.12.2015, p. 588-604.

Research output: Contribution to journalArticle

Rapp, Brenda C ; Purcell, Jeremy ; Hillis-Trupe, Argye ; Capasso, Rita ; Miceli, Gabriele. / Neural bases of orthographic long-term memory and working memory in dysgraphia. In: Brain. 2015 ; Vol. 139, No. 2. pp. 588-604.
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