Network-based modular markers of aging across different tissues

Aristidis G. Vrahatis; Konstantina Dimitrakopoulou; Georgios N. Dimitrakopoulos; Kyriakos N. Sgarbas; Athanasios K. Tsakalidis; Anastasios Bezerianos

doi:10.1007/978-3-319-00846-2_456

Network-based modular markers of aging across different tissues

Aristidis G. Vrahatis, Konstantina Dimitrakopoulou, Georgios N. Dimitrakopoulos, Kyriakos N. Sgarbas, Athanasios K. Tsakalidis, Anastasios Bezerianos

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Aging is a highly complex biological process and a risk factor for many diseases. Motivated by the high availability of diverse high-throughput data in the mouse model organism, we provide a systemic view of the age-related mechanisms. In particular, we present a robust network-based integrative approach that provides, based on protein interaction and microarray data, reliable modules that alter significantly in terms of expression during aging. Our modular meta-analysis provides novel information about the involvement of several established as well as recently reported longevity-associated pathways across different tissues.

Original language	English (US)
Title of host publication	13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013 - MEDICON 2013
Publisher	Springer Verlag
Pages	1849-1852
Number of pages	4
ISBN (Print)	9783319008455
DOIs	https://doi.org/10.1007/978-3-319-00846-2_456
State	Published - 2014
Event	13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013, MEDICON 2013 - Seville, Spain Duration: Sep 25 2013 → Sep 28 2013

Publication series

Name	IFMBE Proceedings
Volume	41
ISSN (Print)	1680-0737

Other

Other	13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013, MEDICON 2013
Country/Territory	Spain
City	Seville
Period	9/25/13 → 9/28/13

Keywords

Aging
Microarray
Module
Protein interaction

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

Access to Document

10.1007/978-3-319-00846-2_456

Cite this

Vrahatis, A. G., Dimitrakopoulou, K., Dimitrakopoulos, G. N., Sgarbas, K. N., Tsakalidis, A. K., & Bezerianos, A. (2014). Network-based modular markers of aging across different tissues. In 13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013 - MEDICON 2013 (pp. 1849-1852). (IFMBE Proceedings; Vol. 41). Springer Verlag. https://doi.org/10.1007/978-3-319-00846-2_456

Network-based modular markers of aging across different tissues. / Vrahatis, Aristidis G.; Dimitrakopoulou, Konstantina; Dimitrakopoulos, Georgios N. et al.

13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013 - MEDICON 2013. Springer Verlag, 2014. p. 1849-1852 (IFMBE Proceedings; Vol. 41).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Vrahatis, AG, Dimitrakopoulou, K, Dimitrakopoulos, GN, Sgarbas, KN, Tsakalidis, AK & Bezerianos, A 2014, Network-based modular markers of aging across different tissues. in 13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013 - MEDICON 2013. IFMBE Proceedings, vol. 41, Springer Verlag, pp. 1849-1852, 13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013, MEDICON 2013, Seville, Spain, 9/25/13. https://doi.org/10.1007/978-3-319-00846-2_456

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AU - Dimitrakopoulou, Konstantina

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AU - Sgarbas, Kyriakos N.

AU - Tsakalidis, Athanasios K.

AU - Bezerianos, Anastasios

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AB - Aging is a highly complex biological process and a risk factor for many diseases. Motivated by the high availability of diverse high-throughput data in the mouse model organism, we provide a systemic view of the age-related mechanisms. In particular, we present a robust network-based integrative approach that provides, based on protein interaction and microarray data, reliable modules that alter significantly in terms of expression during aging. Our modular meta-analysis provides novel information about the involvement of several established as well as recently reported longevity-associated pathways across different tissues.

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Network-based modular markers of aging across different tissues

Abstract

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Keywords

ASJC Scopus subject areas

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