Network-based modular markers of aging across different tissues

Aristidis G. Vrahatis, Konstantina Dimitrakopoulou, Georgios N. Dimitrakopoulos, Kyriakos N. Sgarbas, Athanasios K. Tsakalidis, Anastasios Bezerianos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Aging is a highly complex biological process and a risk factor for many diseases. Motivated by the high availability of diverse high-throughput data in the mouse model organism, we provide a systemic view of the age-related mechanisms. In particular, we present a robust network-based integrative approach that provides, based on protein interaction and microarray data, reliable modules that alter significantly in terms of expression during aging. Our modular meta-analysis provides novel information about the involvement of several established as well as recently reported longevity-associated pathways across different tissues.

Original languageEnglish (US)
Title of host publication13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013 - MEDICON 2013
PublisherSpringer Verlag
Pages1849-1852
Number of pages4
ISBN (Print)9783319008455
DOIs
StatePublished - Jan 1 2014
Event13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013, MEDICON 2013 - Seville, Spain
Duration: Sep 25 2013Sep 28 2013

Publication series

NameIFMBE Proceedings
Volume41
ISSN (Print)1680-0737

Other

Other13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013, MEDICON 2013
Country/TerritorySpain
CitySeville
Period9/25/139/28/13

Keywords

  • Aging
  • Microarray
  • Module
  • Protein interaction

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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