TY - GEN
T1 - Network-based modular markers of aging across different tissues
AU - Vrahatis, Aristidis G.
AU - Dimitrakopoulou, Konstantina
AU - Dimitrakopoulos, Georgios N.
AU - Sgarbas, Kyriakos N.
AU - Tsakalidis, Athanasios K.
AU - Bezerianos, Anastasios
PY - 2014
Y1 - 2014
N2 - Aging is a highly complex biological process and a risk factor for many diseases. Motivated by the high availability of diverse high-throughput data in the mouse model organism, we provide a systemic view of the age-related mechanisms. In particular, we present a robust network-based integrative approach that provides, based on protein interaction and microarray data, reliable modules that alter significantly in terms of expression during aging. Our modular meta-analysis provides novel information about the involvement of several established as well as recently reported longevity-associated pathways across different tissues.
AB - Aging is a highly complex biological process and a risk factor for many diseases. Motivated by the high availability of diverse high-throughput data in the mouse model organism, we provide a systemic view of the age-related mechanisms. In particular, we present a robust network-based integrative approach that provides, based on protein interaction and microarray data, reliable modules that alter significantly in terms of expression during aging. Our modular meta-analysis provides novel information about the involvement of several established as well as recently reported longevity-associated pathways across different tissues.
KW - Aging
KW - Microarray
KW - Module
KW - Protein interaction
UR - http://www.scopus.com/inward/record.url?scp=84891301290&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891301290&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-00846-2_456
DO - 10.1007/978-3-319-00846-2_456
M3 - Conference contribution
AN - SCOPUS:84891301290
SN - 9783319008455
T3 - IFMBE Proceedings
SP - 1849
EP - 1852
BT - 13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013 - MEDICON 2013
PB - Springer Verlag
T2 - 13th Mediterranean Conference on Medical and Biological Engineering and Computing 2013, MEDICON 2013
Y2 - 25 September 2013 through 28 September 2013
ER -