Nine Indian patients with bacteriologically-proven cholera diarrhea, 3 with diarrhea attributable to an enteropathogenic strain of Escherichia coli, and 6 Indian male control subjects were studied by means of the triple lumen tube perfusion technique. Net (Jnet) and unidirectional mucosa to serosa (Lm /ar s) and serosa to mucosa (Js → m) l flux rates were measured utilizing 24Na and 3HOH in jejunum and ileum in the acute and convalescent phase of the disease Ali 12 patients with cholera and E. coli diarrhea demonstrated ne+ fluid secretion into the bowel lumen (± 3.05 and ± 1.41 ml. per hour per centimeter), while control subjects demonstrated net fluid absorption (± 0.8 ± 0.35 ml. per hour per centimeter). In all acute diarrheal disease both Js → m and Jm → s flux for sodium and water were increased but the greate increase in Js → m primarily accounted for the change from a normal net absorptive state to net secretion of sodium and water into the intestinal lumen. Unidirectional fluxes of 24Na and 7HOH were increased 3 to 5 fold over convalescent and control levels. An increase in Js → mH2O in the jejunum was correlated with net jejunal fluid secretion (r = 0.75), fasting intestinal (jejunal) flow rates (r = 0.67) and stool output (r = 0.58) in acute cholera diarrhea.
|Original language||English (US)|
|Number of pages||12|
|Journal||The Journal of laboratory and clinical medicine|
|State||Published - Nov 1972|
ASJC Scopus subject areas
- Pathology and Forensic Medicine