Nervy Links Protein Kinase A to Plexin-Mediated Semaphorin Repulsion

Jonathan R. Terman, Alex L. Kolodkin

Research output: Contribution to journalArticlepeer-review

Abstract

Cyclic nucleotides regulate axonal responses to a number of guidance cues through unknown molecular events. We report here that Drosophila nervy, a member of the myeloid translocation gene family of A kinase anchoring proteins (AKAPs), regulates repulsive axon guidance by linking the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) to the Semaphorin 1a (Sema-1a) receptor Plexin A (PlexA). Nervy and PKA antagonize Sema-1a-PlexA-mediated repulsion, and the AKAP binding region of Nervy is critical for this effect. Thus, Nervy couples cAMP-PKA signaling to PlexA to regulate Sema-1a-mediated axonal repulsion, revealing a simple molecular mechanism that allows growing axons to integrate inputs from multiple guidance cues.

Original languageEnglish (US)
Pages (from-to)1204-1207
Number of pages4
JournalScience
Volume303
Issue number5661
DOIs
StatePublished - Feb 20 2004

ASJC Scopus subject areas

  • General

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