Nerve terminal degeneration after a single injection of D-amphetamine in iprindole-treated rats: relation to selective long-lasting dopamine depletion

G. A. Ricaurte, R. W. Guillery, L. S. Seiden, C. R. Schuster

Research output: Contribution to journalArticlepeer-review

Abstract

A single injection of D-amphetamine has recently been shown to produce long-lasting dopamine (DA) deficits in rats pretreated with iprindole, an agent which interferes with the metabolism of amphetamine and prolongs its half-life. The basis for these persistent DA deficits has not been determined. The present results suggest that amphetamine produces prolonged DA depletions in iprindole-treated rats by destroying DA nerve terminals.

Original languageEnglish (US)
Pages (from-to)378-382
Number of pages5
JournalBrain research
Volume291
Issue number2
DOIs
StatePublished - Jan 23 1984
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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