Nerve terminal degeneration after a single injection of D-amphetamine in iprindole-treated rats: relation to selective long-lasting dopamine depletion

G. A. Ricaurte; R. W. Guillery; L. S. Seiden; C. R. Schuster

doi:10.1016/0006-8993(84)91273-3

Nerve terminal degeneration after a single injection of D-amphetamine in iprindole-treated rats: relation to selective long-lasting dopamine depletion

G. A. Ricaurte, R. W. Guillery, L. S. Seiden, C. R. Schuster

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

A single injection of D-amphetamine has recently been shown to produce long-lasting dopamine (DA) deficits in rats pretreated with iprindole, an agent which interferes with the metabolism of amphetamine and prolongs its half-life. The basis for these persistent DA deficits has not been determined. The present results suggest that amphetamine produces prolonged DA depletions in iprindole-treated rats by destroying DA nerve terminals.

Original language	English (US)
Pages (from-to)	378-382
Number of pages	5
Journal	Brain research
Volume	291
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)91273-3
State	Published - Jan 23 1984
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)91273-3

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title = "Nerve terminal degeneration after a single injection of D-amphetamine in iprindole-treated rats: relation to selective long-lasting dopamine depletion",

abstract = "A single injection of D-amphetamine has recently been shown to produce long-lasting dopamine (DA) deficits in rats pretreated with iprindole, an agent which interferes with the metabolism of amphetamine and prolongs its half-life. The basis for these persistent DA deficits has not been determined. The present results suggest that amphetamine produces prolonged DA depletions in iprindole-treated rats by destroying DA nerve terminals.",

author = "Ricaurte, {G. A.} and Guillery, {R. W.} and Seiden, {L. S.} and Schuster, {C. R.}",

note = "Funding Information: We are grateful to Pat Cantwell for her patient help in preparing the manuscript and to S. Price for his help with the illustration. G.A. R, is supported by USPHS GM-07190: C.R.S. and L.S. by DA-00085 and DA-00250. L.S. is the recipient of an RSA; MH-10562. C.R.S. is the recipient of an RSA: DA 00024. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Ricaurte, G. A.

AU - Guillery, R. W.

AU - Seiden, L. S.

AU - Schuster, C. R.

N1 - Funding Information: We are grateful to Pat Cantwell for her patient help in preparing the manuscript and to S. Price for his help with the illustration. G.A. R, is supported by USPHS GM-07190: C.R.S. and L.S. by DA-00085 and DA-00250. L.S. is the recipient of an RSA; MH-10562. C.R.S. is the recipient of an RSA: DA 00024. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1984/1/23

Y1 - 1984/1/23

N2 - A single injection of D-amphetamine has recently been shown to produce long-lasting dopamine (DA) deficits in rats pretreated with iprindole, an agent which interferes with the metabolism of amphetamine and prolongs its half-life. The basis for these persistent DA deficits has not been determined. The present results suggest that amphetamine produces prolonged DA depletions in iprindole-treated rats by destroying DA nerve terminals.

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Nerve terminal degeneration after a single injection of D-amphetamine in iprindole-treated rats: relation to selective long-lasting dopamine depletion

Abstract

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