Nerve regeneration through a pseudosynovial sheath in a primate model

Susan E. Mackinnon, A. Lee Dellon, Alan R. Hudson, Daniel A. Hunter

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated nerve regeneration through a pseudosynovial sheath in a primate. After resecting a 3-cm segment of the ulnar nerve at the elbow, the two ends of the divided nerve were placed at either end of the pseudo- synovial tube, positioning the nerve ends such that they were separated by a 3-cm gap. Histologic evaluation at 3, 5, 7, and 9 months demonstrated evidence of nerve regeneration across this gap. Nerve fiber diameter and density assessment demonstrated a maturation of the fiber pattern with time. The overall morphologic pattern of the regenerating nerve within the pseudosheath was that of multiple small fascicles, each within its own perineurial compartment. This pattern resembled neither the proximal nor distal nerve fascicular pattern.

Original languageEnglish (US)
Pages (from-to)833-839
Number of pages7
JournalPlastic and reconstructive surgery
Volume75
Issue number6
DOIs
StatePublished - Jun 1985

ASJC Scopus subject areas

  • Surgery

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