Nerve regeneration in diabetic rats

Srdan Babovic, Andrew M. Ress, A. Lee Dellon, Michael F. Angel, Michael Im, Paul N. Manson

Research output: Contribution to journalArticle

Abstract

This study evaluated the capacity of diabetic rats to recover the ability to walk after nerve repair or nerve graft of the posterior tibial nerve at thigh level. Functional recovery of the posterior tibial nerve was evaluated by walking track analysis during regeneration in streptozotocin- induced diabetic rats. Surgical procedures were performed 8 weeks after induction of diabetes. The nerve repair was epineurial. The nerve graft was a 1.5 cm segment orthotopically replaced. There was no significant difference in functional recovery between normal and diabetic rats for both the nerve repair and nerve graft groups at 6, 12, and 24 weeks after nerve reconstruction. It is concluded that the presence of diabetes is not a contraindication for nerve reconstruction.

Original languageEnglish (US)
Pages (from-to)9-11
Number of pages3
JournalMicrosurgery
Volume18
Issue number1
DOIs
StatePublished - Jun 20 1998

ASJC Scopus subject areas

  • Surgery

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