Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response

G. Taglialatela, L. Angelucci, S. Scaccianoce, Perry Foreman, J. R. Perez-Polo

Research output: Contribution to journalArticle

Abstract

In the present study, we have investigated the functional relationship between the nerve growth factor protein (NGF) and the hypothalamus-pituitary-adrenocortical axis (HPAA) We have found that while iv injected NGF is able to stimulate the HPAA activity in rats, NGF is not able to stimulate the axis after a block of the hypothalamus produced by chlor-promazine-morphine-Nembutal treatment. Also, the stress ac-tivation of the HPAA is significantly reduced by pretreatment of the rats with anti-NGF immunoglobulin G. These results suggest that the stimulatory action of NGF on HPAA activity requires the release of ACTH secretagogues from the hypothalamus and that NGF may modulate the HPAA response to stress stimuli.

Original languageEnglish (US)
Pages (from-to)2212-2218
Number of pages7
JournalEndocrinology
Volume129
Issue number4
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Nerve Growth Factor
Hypothalamus
Proteins
Promazine
Pentobarbital
Adrenocorticotropic Hormone
Morphine
Immunoglobulin G

ASJC Scopus subject areas

  • Endocrinology

Cite this

Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response. / Taglialatela, G.; Angelucci, L.; Scaccianoce, S.; Foreman, Perry; Perez-Polo, J. R.

In: Endocrinology, Vol. 129, No. 4, 1991, p. 2212-2218.

Research output: Contribution to journalArticle

Taglialatela, G. ; Angelucci, L. ; Scaccianoce, S. ; Foreman, Perry ; Perez-Polo, J. R. / Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response. In: Endocrinology. 1991 ; Vol. 129, No. 4. pp. 2212-2218.
@article{196916bd397a4593b4eb737fa8079a16,
title = "Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response",
abstract = "In the present study, we have investigated the functional relationship between the nerve growth factor protein (NGF) and the hypothalamus-pituitary-adrenocortical axis (HPAA) We have found that while iv injected NGF is able to stimulate the HPAA activity in rats, NGF is not able to stimulate the axis after a block of the hypothalamus produced by chlor-promazine-morphine-Nembutal treatment. Also, the stress ac-tivation of the HPAA is significantly reduced by pretreatment of the rats with anti-NGF immunoglobulin G. These results suggest that the stimulatory action of NGF on HPAA activity requires the release of ACTH secretagogues from the hypothalamus and that NGF may modulate the HPAA response to stress stimuli.",
author = "G. Taglialatela and L. Angelucci and S. Scaccianoce and Perry Foreman and Perez-Polo, {J. R.}",
year = "1991",
doi = "10.1210/endo-129-4-2212",
language = "English (US)",
volume = "129",
pages = "2212--2218",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "4",

}

TY - JOUR

T1 - Nerve growth factor modulates the activation of the hypothalamo-pituitary-adrenocortical axis during the stress response

AU - Taglialatela, G.

AU - Angelucci, L.

AU - Scaccianoce, S.

AU - Foreman, Perry

AU - Perez-Polo, J. R.

PY - 1991

Y1 - 1991

N2 - In the present study, we have investigated the functional relationship between the nerve growth factor protein (NGF) and the hypothalamus-pituitary-adrenocortical axis (HPAA) We have found that while iv injected NGF is able to stimulate the HPAA activity in rats, NGF is not able to stimulate the axis after a block of the hypothalamus produced by chlor-promazine-morphine-Nembutal treatment. Also, the stress ac-tivation of the HPAA is significantly reduced by pretreatment of the rats with anti-NGF immunoglobulin G. These results suggest that the stimulatory action of NGF on HPAA activity requires the release of ACTH secretagogues from the hypothalamus and that NGF may modulate the HPAA response to stress stimuli.

AB - In the present study, we have investigated the functional relationship between the nerve growth factor protein (NGF) and the hypothalamus-pituitary-adrenocortical axis (HPAA) We have found that while iv injected NGF is able to stimulate the HPAA activity in rats, NGF is not able to stimulate the axis after a block of the hypothalamus produced by chlor-promazine-morphine-Nembutal treatment. Also, the stress ac-tivation of the HPAA is significantly reduced by pretreatment of the rats with anti-NGF immunoglobulin G. These results suggest that the stimulatory action of NGF on HPAA activity requires the release of ACTH secretagogues from the hypothalamus and that NGF may modulate the HPAA response to stress stimuli.

UR - http://www.scopus.com/inward/record.url?scp=0026048161&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026048161&partnerID=8YFLogxK

U2 - 10.1210/endo-129-4-2212

DO - 10.1210/endo-129-4-2212

M3 - Article

C2 - 1915102

AN - SCOPUS:0026048161

VL - 129

SP - 2212

EP - 2218

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 4

ER -