Nerve growth factor and p75NGFR factor receptor mRNA change in rodent CNS following stress activation of the hypothalamo‐pituitary‐adrenocortical axis

Perry Foreman, G. Taglialatela, L. Angelucci, C. P. Turner, J. R. Perez‐Polo

Research output: Contribution to journalReview article

Abstract

The synthesis of nerve growth factor (NGF) by the hippocampus raises the possibility that NGF may play a role in the regulation of the hypothalamic‐pituitary‐adrenal axis (HPAA). Subchronic cold stress has been shown to activate the HPAA in a mild noninvasive manner, to stimulate serum glucocorticoid levels, and to perturb NGF binding in hippocampus and basal forebrain. One or repeated episodes of cold stress increased NGF mRNA levels in the hippocampus and p75NGFR mRNA levels in the basal forebrain. These changes were not due to elevated serum glucocorticoid levels since treatment with exogenous corticosterone had no effect on NGF and p75NGFR mRNA levels. Adrenalectomy did not prevent the stress induced increases in NGF and p75NGFR mRNA. © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)10-18
Number of pages9
JournalJournal of Neuroscience Research
Volume36
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Nerve Growth Factor
Rodentia
Messenger RNA
Hippocampus
Glucocorticoids
Adrenalectomy
Corticosterone
Serum

Keywords

  • corticosteroid
  • hypothalamus
  • neurotrophin receptor
  • stress hippocampus

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Nerve growth factor and p75NGFR factor receptor mRNA change in rodent CNS following stress activation of the hypothalamo‐pituitary‐adrenocortical axis. / Foreman, Perry; Taglialatela, G.; Angelucci, L.; Turner, C. P.; Perez‐Polo, J. R.

In: Journal of Neuroscience Research, Vol. 36, No. 1, 1993, p. 10-18.

Research output: Contribution to journalReview article

@article{0df70f792cd647ce99645b2084afa493,
title = "Nerve growth factor and p75NGFR factor receptor mRNA change in rodent CNS following stress activation of the hypothalamo‐pituitary‐adrenocortical axis",
abstract = "The synthesis of nerve growth factor (NGF) by the hippocampus raises the possibility that NGF may play a role in the regulation of the hypothalamic‐pituitary‐adrenal axis (HPAA). Subchronic cold stress has been shown to activate the HPAA in a mild noninvasive manner, to stimulate serum glucocorticoid levels, and to perturb NGF binding in hippocampus and basal forebrain. One or repeated episodes of cold stress increased NGF mRNA levels in the hippocampus and p75NGFR mRNA levels in the basal forebrain. These changes were not due to elevated serum glucocorticoid levels since treatment with exogenous corticosterone had no effect on NGF and p75NGFR mRNA levels. Adrenalectomy did not prevent the stress induced increases in NGF and p75NGFR mRNA. {\circledC} 1993 Wiley‐Liss, Inc.",
keywords = "corticosteroid, hypothalamus, neurotrophin receptor, stress hippocampus",
author = "Perry Foreman and G. Taglialatela and L. Angelucci and Turner, {C. P.} and Perez‐Polo, {J. R.}",
year = "1993",
doi = "10.1002/jnr.490360103",
language = "English (US)",
volume = "36",
pages = "10--18",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Nerve growth factor and p75NGFR factor receptor mRNA change in rodent CNS following stress activation of the hypothalamo‐pituitary‐adrenocortical axis

AU - Foreman, Perry

AU - Taglialatela, G.

AU - Angelucci, L.

AU - Turner, C. P.

AU - Perez‐Polo, J. R.

PY - 1993

Y1 - 1993

N2 - The synthesis of nerve growth factor (NGF) by the hippocampus raises the possibility that NGF may play a role in the regulation of the hypothalamic‐pituitary‐adrenal axis (HPAA). Subchronic cold stress has been shown to activate the HPAA in a mild noninvasive manner, to stimulate serum glucocorticoid levels, and to perturb NGF binding in hippocampus and basal forebrain. One or repeated episodes of cold stress increased NGF mRNA levels in the hippocampus and p75NGFR mRNA levels in the basal forebrain. These changes were not due to elevated serum glucocorticoid levels since treatment with exogenous corticosterone had no effect on NGF and p75NGFR mRNA levels. Adrenalectomy did not prevent the stress induced increases in NGF and p75NGFR mRNA. © 1993 Wiley‐Liss, Inc.

AB - The synthesis of nerve growth factor (NGF) by the hippocampus raises the possibility that NGF may play a role in the regulation of the hypothalamic‐pituitary‐adrenal axis (HPAA). Subchronic cold stress has been shown to activate the HPAA in a mild noninvasive manner, to stimulate serum glucocorticoid levels, and to perturb NGF binding in hippocampus and basal forebrain. One or repeated episodes of cold stress increased NGF mRNA levels in the hippocampus and p75NGFR mRNA levels in the basal forebrain. These changes were not due to elevated serum glucocorticoid levels since treatment with exogenous corticosterone had no effect on NGF and p75NGFR mRNA levels. Adrenalectomy did not prevent the stress induced increases in NGF and p75NGFR mRNA. © 1993 Wiley‐Liss, Inc.

KW - corticosteroid

KW - hypothalamus

KW - neurotrophin receptor

KW - stress hippocampus

UR - http://www.scopus.com/inward/record.url?scp=0027317440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027317440&partnerID=8YFLogxK

U2 - 10.1002/jnr.490360103

DO - 10.1002/jnr.490360103

M3 - Review article

VL - 36

SP - 10

EP - 18

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 1

ER -