Nerve growth factor and neuronal cell death

J. Regino Perez-Polo; Perry J. Foreman; George R. Jackson; Din e. Shan; Giulio Taglialatela; Larry W. Thorpe; Karin Werrbach-Perez

doi:10.1007/BF02935585

Nerve growth factor and neuronal cell death

J. Regino Perez-Polo, Perry J. Foreman, George R. Jackson, Din e. Shan, Giulio Taglialatela, Larry W. Thorpe, Karin Werrbach-Perez

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The regulation of neuronal cell death by the neuronotrophic factor, nerve growth factor (NGF), has been described during neural development and following injury to the nervous system. Also, reduced NGF activity has been reported for the aged NGF-responsive neurons of the sympathetic nervous system and cholinergic regions of the central nervous system (CNS) in aged rodents and man. Although there is some knowledge of the molecular structure of the NGF and its receptor, less is known as to the mechanism of action of NGF. Here, a possible role for NGF in the regulation of oxidant-antioxidant balance is discussed as part of a molecular explanation for the known effects of NGF on neuronal survival during development, after injury, and in the aged CNS.

Original language	English (US)
Pages (from-to)	57-91
Number of pages	35
Journal	Molecular Neurobiology
Volume	4
Issue number	1-2
DOIs	https://doi.org/10.1007/BF02935585
State	Published - Mar 1990
Externally published	Yes

Keywords

NGF
NGF receptor
acetyl-l-carnitine
aged
astrocyte lymphocyte
cell death
growth factor
mitogen
neurotrophic factor
purification
receptor-associated protein
retinoic acid

ASJC Scopus subject areas

Neurology
Cellular and Molecular Neuroscience

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10.1007/BF02935585

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title = "Nerve growth factor and neuronal cell death",

abstract = "The regulation of neuronal cell death by the neuronotrophic factor, nerve growth factor (NGF), has been described during neural development and following injury to the nervous system. Also, reduced NGF activity has been reported for the aged NGF-responsive neurons of the sympathetic nervous system and cholinergic regions of the central nervous system (CNS) in aged rodents and man. Although there is some knowledge of the molecular structure of the NGF and its receptor, less is known as to the mechanism of action of NGF. Here, a possible role for NGF in the regulation of oxidant-antioxidant balance is discussed as part of a molecular explanation for the known effects of NGF on neuronal survival during development, after injury, and in the aged CNS.",

keywords = "NGF, NGF receptor, acetyl-l-carnitine, aged, astrocyte lymphocyte, cell death, growth factor, mitogen, neurotrophic factor, purification, receptor-associated protein, retinoic acid",

author = "Perez-Polo, {J. Regino} and Foreman, {Perry J.} and Jackson, {George R.} and Shan, {Din e.} and Giulio Taglialatela and Thorpe, {Larry W.} and Karin Werrbach-Perez",

year = "1990",

month = mar,

doi = "10.1007/BF02935585",

language = "English (US)",

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AU - Perez-Polo, J. Regino

AU - Foreman, Perry J.

AU - Jackson, George R.

AU - Shan, Din e.

AU - Taglialatela, Giulio

AU - Thorpe, Larry W.

AU - Werrbach-Perez, Karin

PY - 1990/3

Y1 - 1990/3

N2 - The regulation of neuronal cell death by the neuronotrophic factor, nerve growth factor (NGF), has been described during neural development and following injury to the nervous system. Also, reduced NGF activity has been reported for the aged NGF-responsive neurons of the sympathetic nervous system and cholinergic regions of the central nervous system (CNS) in aged rodents and man. Although there is some knowledge of the molecular structure of the NGF and its receptor, less is known as to the mechanism of action of NGF. Here, a possible role for NGF in the regulation of oxidant-antioxidant balance is discussed as part of a molecular explanation for the known effects of NGF on neuronal survival during development, after injury, and in the aged CNS.

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KW - NGF

KW - NGF receptor

KW - acetyl-l-carnitine

KW - aged

KW - astrocyte lymphocyte

KW - cell death

KW - growth factor

KW - mitogen

KW - neurotrophic factor

KW - purification

KW - receptor-associated protein

KW - retinoic acid

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JF - Molecular Neurobiology

IS - 1-2

ER -

Nerve growth factor and neuronal cell death

Abstract

Keywords

ASJC Scopus subject areas

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