Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

David D. Ginty, Azad Bonni, Michael E. Greenberg

Research output: Contribution to journalArticlepeer-review

Abstract

A mechanism by which the nerve growth factor (NGF) signal is transduced to the nucleus to induce gene expression has been characterized. An NGF-inducible, Ras-dependent protein kinase has been identified that catalyzes the phosphorylation of the cyclic AMP response element-binding protein (CREB) at Ser-133. Phosphorylation of Ser-133 stimulates the ability of CREB to activate transcription in NGF-treated cells. These findings suggest that CREB has a more widespread function than previously believed and functions in the nucleus as a general mediator of growth factor responses.

Original languageEnglish (US)
Pages (from-to)713-725
Number of pages13
JournalCell
Volume77
Issue number5
DOIs
StatePublished - Jun 3 1994
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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