Abstract
A mechanism by which the nerve growth factor (NGF) signal is transduced to the nucleus to induce gene expression has been characterized. An NGF-inducible, Ras-dependent protein kinase has been identified that catalyzes the phosphorylation of the cyclic AMP response element-binding protein (CREB) at Ser-133. Phosphorylation of Ser-133 stimulates the ability of CREB to activate transcription in NGF-treated cells. These findings suggest that CREB has a more widespread function than previously believed and functions in the nucleus as a general mediator of growth factor responses.
Original language | English (US) |
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Pages (from-to) | 713-725 |
Number of pages | 13 |
Journal | Cell |
Volume | 77 |
Issue number | 5 |
DOIs | |
State | Published - Jun 3 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology