Nephrogenic adenoma and embryonic kidney tubules share PNA receptor sites

P. Devine, A. A. Ucci, H. Krain, V. E. Gavris, Belur Bhagavan, J. A. Heaney, J. Alroy

Research output: Contribution to journalArticle

Abstract

Nephrogenic adenoma a rare bladder, ureter, or urethral lesion, is of disputed pathogenesis, metaplastic and congenital etiologies both being implicated in its development. Since light and electron microscopy have been unable to fully resolve the lesion's pathogenesis, the authors used biotinylated lectins as probes and avidin-biotin peroxidase complex (ABC) as a visualant to study cases of nephrogenic adenomas and compared their lectin binding patterns with those of normal transitional epithelium, human embryonic kidneys, and cases of cystitis cystica and glandularis and squamous metaplasia of the bladder in an effort to clarify this tissue. Only the epithelial lining of the luminal surface and tubuli in nephrogenic adenoma and tubules in embryonic kidney exhibited free PNA receptor sites. The striking staining similarities between the epithelial components of nephrogenic adenomas and mesonephric and metanephric tubules complement previous findings concerning the origin of nephrogenic adenoma.

Original languageEnglish (US)
Pages (from-to)728-732
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume81
Issue number6
StatePublished - 1984
Externally publishedYes

Fingerprint

Kidney Tubules
Adenoma
Lectins
Urinary Bladder
Kidney
Cystitis
Avidin
Metaplasia
Ureter
Biotin
Peroxidase
Electron Microscopy
Epithelium
Staining and Labeling
Light

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Devine, P., Ucci, A. A., Krain, H., Gavris, V. E., Bhagavan, B., Heaney, J. A., & Alroy, J. (1984). Nephrogenic adenoma and embryonic kidney tubules share PNA receptor sites. American Journal of Clinical Pathology, 81(6), 728-732.

Nephrogenic adenoma and embryonic kidney tubules share PNA receptor sites. / Devine, P.; Ucci, A. A.; Krain, H.; Gavris, V. E.; Bhagavan, Belur; Heaney, J. A.; Alroy, J.

In: American Journal of Clinical Pathology, Vol. 81, No. 6, 1984, p. 728-732.

Research output: Contribution to journalArticle

Devine, P, Ucci, AA, Krain, H, Gavris, VE, Bhagavan, B, Heaney, JA & Alroy, J 1984, 'Nephrogenic adenoma and embryonic kidney tubules share PNA receptor sites', American Journal of Clinical Pathology, vol. 81, no. 6, pp. 728-732.
Devine, P. ; Ucci, A. A. ; Krain, H. ; Gavris, V. E. ; Bhagavan, Belur ; Heaney, J. A. ; Alroy, J. / Nephrogenic adenoma and embryonic kidney tubules share PNA receptor sites. In: American Journal of Clinical Pathology. 1984 ; Vol. 81, No. 6. pp. 728-732.
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