Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells

John Paul Ridge, Ephraim J. Fuchs, Polly Matzinger

Research output: Contribution to journalArticle

Abstract

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.

Original languageEnglish (US)
Pages (from-to)1723-1726
Number of pages4
JournalScience
Volume271
Issue number5256
DOIs
StatePublished - Mar 22 1996

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