Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells

John Paul Ridge; Ephraim J. Fuchs; Polly Matzinger

doi:10.1126/science.271.5256.1723

Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells

John Paul Ridge, Ephraim J. Fuchs, Polly Matzinger

School of Medicine

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664 Scopus citations

Abstract

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.

Original language	English (US)
Pages (from-to)	1723-1726
Number of pages	4
Journal	Science
Volume	271
Issue number	5256
DOIs	https://doi.org/10.1126/science.271.5256.1723
State	Published - Mar 22 1996

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title = "Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells",

abstract = "For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.",

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Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells

Abstract

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