Neonatal thymectomy increases the incidence of spontaneous and methylcholanthrene-enhanced thyroiditis in rats

David A. Silverman, Noel R. Rose

Research output: Contribution to journalArticle

Abstract

At 16 weeks of age, 13 percent of untreated Buffalo strain rats showed evidence of autoimmune thyroiditis. Feeding methylcholanthrene increased the incidence to 42 percent. Neonatal thymectomy significantly raised the incidence of disease so that almost all (87 percent) untreated and all methylcholanthrene-treated animals developed severe disease. It is proposed that the thymus exerts a regulatory effect on autosensitization.

Original languageEnglish (US)
Pages (from-to)162-163
Number of pages2
JournalScience
Volume184
Issue number4133
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Neonatal thymectomy increases the incidence of spontaneous and methylcholanthrene-enhanced thyroiditis in rats'. Together they form a unique fingerprint.

  • Cite this