Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test

L. Vernacchio, G. Madico, M. Verastegui, F. Diaz, T. S. Collins, Robert H Gilman

Research output: Contribution to journalArticle

Abstract

We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (≥0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world.

Original languageEnglish (US)
Pages (from-to)1754-1756
Number of pages3
JournalAmerican Journal of Public Health
Volume83
Issue number12
StatePublished - 1993

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Toxoids
Peru
Tetanus
Skin Tests
Enzyme-Linked Immunosorbent Assay
Immunity
Antitoxins
Pregnancy
Prenatal Care
Pregnant Women
Delivery of Health Care

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Neonatal tetanus in Peru : Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test. / Vernacchio, L.; Madico, G.; Verastegui, M.; Diaz, F.; Collins, T. S.; Gilman, Robert H.

In: American Journal of Public Health, Vol. 83, No. 12, 1993, p. 1754-1756.

Research output: Contribution to journalArticle

Vernacchio, L, Madico, G, Verastegui, M, Diaz, F, Collins, TS & Gilman, RH 1993, 'Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test', American Journal of Public Health, vol. 83, no. 12, pp. 1754-1756.
Vernacchio, L. ; Madico, G. ; Verastegui, M. ; Diaz, F. ; Collins, T. S. ; Gilman, Robert H. / Neonatal tetanus in Peru : Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test. In: American Journal of Public Health. 1993 ; Vol. 83, No. 12. pp. 1754-1756.
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