Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test

L. Vernacchio; G. Madico; M. Verastegui; F. Diaz; T. S. Collins; R. H. Gilman

doi:10.2105/AJPH.83.12.1754

Neonatal tetanus in Peru: Risk assessment with modified enzyme-linked immunosorbent assay and toxoid skin test

L. Vernacchio, G. Madico, M. Verastegui, F. Diaz, T. S. Collins, R. H. Gilman

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

We used a modified enzyme-linked immunosorbent assay (ELISA) to investigate tetanus immunity in 232 pregnant Peruvian women. One hundred forty-two (61.2%) had protective antitoxin titers (≥0.01 IU/mL). Protective titers correlated positively with the number of toxoid doses reported during the current pregnancy. A majority of women reporting no toxoid doses during the current pregnancy had at least one prenatal health care visit. We evaluated a toxoid skin test in 44 of the subjects, but it correlated poorly with the ELISA. The modified ELISA is a useful in vitro method for studying tetanus immunity in the developing world.

Original language	English (US)
Pages (from-to)	1754-1756
Number of pages	3
Journal	American journal of public health
Volume	83
Issue number	12
DOIs	https://doi.org/10.2105/AJPH.83.12.1754
State	Published - 1993

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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AU - Diaz, F.

AU - Collins, T. S.

AU - Gilman, R. H.

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