Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice

Wendy F. Sternberg; Jeffrey S. Mogil; Benjamin Kest; Gayle G. Page; Yet Leong; Ving Yam; John C. Liebeskind

doi:10.1016/0304-3959(95)00059-3

Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice

Wendy F. Sternberg, Jeffrey S. Mogil, Benjamin Kest, Gayle G. Page, Yet Leong, Ving Yam, John C. Liebeskind

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swiss-Webster mice are sexually dimorphic. Male mice exhibit non-opioid SSIA following a 3-min swim in cold (15°C) water that is antagonized by the non-competitive NMDA antagonist MK-801 (dizocilpine; 0.075 mg/kg), whereas female mice do not display NMDA-mediated analgesia in the presence of estrogen. Since male and female mice show equipotent magnitudes of SSIA, it was concluded that female mice display a neurochemically distinct, estrogen-dependent SSIA mechanism specific to their gender. In the present study, female mice exposed to testosterone during the neonatal period display NMDA-mediated analgesia even in the presence of estrogen in adulthood. Thus, expression of the female-specific, estrogen-dependent SSIA mechanism previously described may be dependent on the absence of testosterone during early ontogeny.

Original language	English (US)
Pages (from-to)	321-326
Number of pages	6
Journal	Pain
Volume	63
Issue number	3
DOIs	https://doi.org/10.1016/0304-3959(95)00059-3
State	Published - Dec 1995
Externally published	Yes

Keywords

Dizocilpine
Estrogen
N-methyl-d-aspartic acid
Swim stress-induced analgesia
Testosterone

ASJC Scopus subject areas

Neurology
Clinical Neurology
Anesthesiology and Pain Medicine

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10.1016/0304-3959(95)00059-3

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title = "Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice",

abstract = "The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swiss-Webster mice are sexually dimorphic. Male mice exhibit non-opioid SSIA following a 3-min swim in cold (15°C) water that is antagonized by the non-competitive NMDA antagonist MK-801 (dizocilpine; 0.075 mg/kg), whereas female mice do not display NMDA-mediated analgesia in the presence of estrogen. Since male and female mice show equipotent magnitudes of SSIA, it was concluded that female mice display a neurochemically distinct, estrogen-dependent SSIA mechanism specific to their gender. In the present study, female mice exposed to testosterone during the neonatal period display NMDA-mediated analgesia even in the presence of estrogen in adulthood. Thus, expression of the female-specific, estrogen-dependent SSIA mechanism previously described may be dependent on the absence of testosterone during early ontogeny.",

keywords = "Dizocilpine, Estrogen, N-methyl-d-aspartic acid, Swim stress-induced analgesia, Testosterone",

author = "Sternberg, {Wendy F.} and Mogil, {Jeffrey S.} and Benjamin Kest and Page, {Gayle G.} and Yet Leong and Ving Yam and Liebeskind, {John C.}",

note = "Funding Information: We would like to thank Herb Washington, and the vivarium staff for the excellent care of the animals used in this research. This paper is dedicated to the memory of Willie Johnson of the Psychology vivarium staff for his many years of dedication and service. This work was supported by NIH Grant NS0278, and an Unrestricted Pain Research Grant from the Bristol-Myers Squibb Company. W.F.S. was also supported by an Individual NRSA, and the UCLA Cota-Robles Dissertation Year Fellowship.",

year = "1995",

month = dec,

doi = "10.1016/0304-3959(95)00059-3",

language = "English (US)",

volume = "63",

pages = "321--326",

journal = "Pain",

issn = "0304-3959",

publisher = "Elsevier",

number = "3",

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T1 - Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice

AU - Sternberg, Wendy F.

AU - Mogil, Jeffrey S.

AU - Kest, Benjamin

AU - Page, Gayle G.

AU - Leong, Yet

AU - Yam, Ving

AU - Liebeskind, John C.

N1 - Funding Information: We would like to thank Herb Washington, and the vivarium staff for the excellent care of the animals used in this research. This paper is dedicated to the memory of Willie Johnson of the Psychology vivarium staff for his many years of dedication and service. This work was supported by NIH Grant NS0278, and an Unrestricted Pain Research Grant from the Bristol-Myers Squibb Company. W.F.S. was also supported by an Individual NRSA, and the UCLA Cota-Robles Dissertation Year Fellowship.

PY - 1995/12

Y1 - 1995/12

N2 - The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swiss-Webster mice are sexually dimorphic. Male mice exhibit non-opioid SSIA following a 3-min swim in cold (15°C) water that is antagonized by the non-competitive NMDA antagonist MK-801 (dizocilpine; 0.075 mg/kg), whereas female mice do not display NMDA-mediated analgesia in the presence of estrogen. Since male and female mice show equipotent magnitudes of SSIA, it was concluded that female mice display a neurochemically distinct, estrogen-dependent SSIA mechanism specific to their gender. In the present study, female mice exposed to testosterone during the neonatal period display NMDA-mediated analgesia even in the presence of estrogen in adulthood. Thus, expression of the female-specific, estrogen-dependent SSIA mechanism previously described may be dependent on the absence of testosterone during early ontogeny.

AB - The effects of neonatal hormone manipulations on swim stress-induced analgesia (SSIA) magnitude and neurochemical quality were examined in Swiss-Webster mice of both sexes. Previous research has indicated that non-opioid SSIA mechanisms in adult Swiss-Webster mice are sexually dimorphic. Male mice exhibit non-opioid SSIA following a 3-min swim in cold (15°C) water that is antagonized by the non-competitive NMDA antagonist MK-801 (dizocilpine; 0.075 mg/kg), whereas female mice do not display NMDA-mediated analgesia in the presence of estrogen. Since male and female mice show equipotent magnitudes of SSIA, it was concluded that female mice display a neurochemically distinct, estrogen-dependent SSIA mechanism specific to their gender. In the present study, female mice exposed to testosterone during the neonatal period display NMDA-mediated analgesia even in the presence of estrogen in adulthood. Thus, expression of the female-specific, estrogen-dependent SSIA mechanism previously described may be dependent on the absence of testosterone during early ontogeny.

KW - Dizocilpine

KW - Estrogen

KW - N-methyl-d-aspartic acid

KW - Swim stress-induced analgesia

KW - Testosterone

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JO - Pain

JF - Pain

SN - 0304-3959

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ER -

Neonatal testosterone exposure influences neurochemistry of non-opioid swim stress-induced analgesia in adult mice

Abstract

Keywords

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