Neonatal neurobehavior effects following buprenorphine versus methadone exposure

Mara G. Coyle, Amy L. Salisbury, Barry M. Lester, Hendrée E. Jones, Hai Lin, Klaudia Graf-Rohrmeister, Gabriele Fischer

Research output: Contribution to journalArticle

Abstract

Aim: To determine the effects of in utero exposure to methadone or buprenorphine on infant neurobehavior. Design: Three sites from the Maternal Opioid Treatment: Human Experimental Research (MOTHER) study, a double-blind, double-dummy, randomized clinical trial participated in this substudy. Setting: Medical Centers that provided comprehensive maternal care to opioid-dependent pregnant women in Baltimore, MD, Providence, RI and Vienna, Austria. Participants: Thirty-nine full-term infants. Measurements: The Neonatal Intensive Care Unit (NICU) Network Neurobehavioral Scale (NNNS) was administered to a subgroup of infants on postpartum days 3, 5, 7, 10, 14-15 and 28-30. Findings: While neurobehavior improved for both medication conditions over time, infants exposed in utero to buprenorphine exhibited fewer stress-abstinence signs (P

Original languageEnglish (US)
Pages (from-to)63-73
Number of pages11
JournalAddiction
Volume107
Issue numberSUPPL.1
DOIs
StatePublished - Nov 2012

Fingerprint

Buprenorphine
Methadone
Opioid Analgesics
Mothers
Baltimore
Austria
Neonatal Intensive Care Units
Double-Blind Method
Postpartum Period
Pregnant Women
Randomized Controlled Trials
Research
Therapeutics

Keywords

  • Full-term infant
  • Neonatal abstinence syndrome
  • Neurobehavior
  • NICU Network Neurobehavioral Scale (NNNS)
  • Opioid exposed newborn

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

Coyle, M. G., Salisbury, A. L., Lester, B. M., Jones, H. E., Lin, H., Graf-Rohrmeister, K., & Fischer, G. (2012). Neonatal neurobehavior effects following buprenorphine versus methadone exposure. Addiction, 107(SUPPL.1), 63-73. https://doi.org/10.1111/j.1360-0443.2012.04040.x

Neonatal neurobehavior effects following buprenorphine versus methadone exposure. / Coyle, Mara G.; Salisbury, Amy L.; Lester, Barry M.; Jones, Hendrée E.; Lin, Hai; Graf-Rohrmeister, Klaudia; Fischer, Gabriele.

In: Addiction, Vol. 107, No. SUPPL.1, 11.2012, p. 63-73.

Research output: Contribution to journalArticle

Coyle, MG, Salisbury, AL, Lester, BM, Jones, HE, Lin, H, Graf-Rohrmeister, K & Fischer, G 2012, 'Neonatal neurobehavior effects following buprenorphine versus methadone exposure', Addiction, vol. 107, no. SUPPL.1, pp. 63-73. https://doi.org/10.1111/j.1360-0443.2012.04040.x
Coyle MG, Salisbury AL, Lester BM, Jones HE, Lin H, Graf-Rohrmeister K et al. Neonatal neurobehavior effects following buprenorphine versus methadone exposure. Addiction. 2012 Nov;107(SUPPL.1):63-73. https://doi.org/10.1111/j.1360-0443.2012.04040.x
Coyle, Mara G. ; Salisbury, Amy L. ; Lester, Barry M. ; Jones, Hendrée E. ; Lin, Hai ; Graf-Rohrmeister, Klaudia ; Fischer, Gabriele. / Neonatal neurobehavior effects following buprenorphine versus methadone exposure. In: Addiction. 2012 ; Vol. 107, No. SUPPL.1. pp. 63-73.
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