Neonatal Lupus Erythematosus: Report of Four Cases With Review of the Literature

Eric C. Vonderheid, Peter J. Koblenzer, Pen Ming L Ming, Carroll F. Burgoon

Research output: Contribution to journalArticle

Abstract

We report four newborn infants with a distinctive evanescent cutaneous eruption that clinically and histologically resembled lupus erythematosus; two of the mothers had undifferentiated connective tissue disease. The tendency for lesions to occur in a periorbital location and the association of prominent telangiectasias were characteristic clinical signs in our patients. Immunoglobulin deposition at the basement membrane was demonstrated in one patient. Cytogenetic studies, done to exclude Bloom syndrome, revealed only nonspecific chromosomal abnormalities. A brief review of the literature, with speculations on the possible relationship of these changes to the occurrence of connective tissue disease in the mothers, is included in the discussion.

Original languageEnglish (US)
Pages (from-to)698-705
Number of pages8
JournalArchives of Dermatology
Volume112
Issue number5
DOIs
StatePublished - 1976
Externally publishedYes

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Connective Tissue Diseases
Bloom Syndrome
Mothers
Telangiectasis
Basement Membrane
Cytogenetics
Chromosome Aberrations
Immunoglobulins
Newborn Infant
Skin
Neonatal Systemic lupus erythematosus

ASJC Scopus subject areas

  • Dermatology

Cite this

Neonatal Lupus Erythematosus : Report of Four Cases With Review of the Literature. / Vonderheid, Eric C.; Koblenzer, Peter J.; Ming, Pen Ming L; Burgoon, Carroll F.

In: Archives of Dermatology, Vol. 112, No. 5, 1976, p. 698-705.

Research output: Contribution to journalArticle

Vonderheid, Eric C. ; Koblenzer, Peter J. ; Ming, Pen Ming L ; Burgoon, Carroll F. / Neonatal Lupus Erythematosus : Report of Four Cases With Review of the Literature. In: Archives of Dermatology. 1976 ; Vol. 112, No. 5. pp. 698-705.
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