Neonatal Leukocyte Physiology and Disorders

John T. Benjamin, Benjamin A. Torres, Akhil Maheshwari

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The developing neonate is exposed to a plethora of antigens and must evolve innate and adaptive immune responses to combat pathogenic microorganisms and at the same time, develop tolerance to self-antigens and commensal microbes. While some components of the immune system are functionally at par with adults, immaturity in others may result in a state of immunodeficiency in the neonate. This chapter highlights the qualitative and quantitative differences in distribution and function of leukocyte populations that together shape the immune responses in the fetus, neonate and the adult. Knowledge of these differences may enable a better understanding of the inherent susceptibility of the neonate to various infections.

Original languageEnglish (US)
Title of host publicationAvery's Diseases of the Newborn
Subtitle of host publicationTenth Edition
PublisherElsevier Inc.
Pages1187-1197.e4
ISBN (Electronic)9780323401722
ISBN (Print)9780323401395
DOIs
StatePublished - 2018
Externally publishedYes

Keywords

  • Development
  • Innate and adaptive immunity
  • Leukocytes
  • Phagocytes

ASJC Scopus subject areas

  • Medicine(all)

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