The developing neonate is exposed to a plethora of antigens and must evolve innate and adaptive immune responses to combat pathogenic microorganisms and at the same time, develop tolerance to self-antigens and commensal microbes. While some components of the immune system are functionally at par with adults, immaturity in others may result in a state of immunodeficiency in the neonate. This chapter highlights the qualitative and quantitative differences in distribution and function of leukocyte populations that together shape the immune responses in the fetus, neonate and the adult. Knowledge of these differences may enable a better understanding of the inherent susceptibility of the neonate to various infections.
|Original language||English (US)|
|Title of host publication||Avery's Diseases of the Newborn|
|Subtitle of host publication||Tenth Edition|
|State||Published - 2018|
- Innate and adaptive immunity
ASJC Scopus subject areas