Neonatal hypocalcaemic seizures

Case report and literature review

Eric H Kossoff, Mary T. Silvia, Alexander Maret, Mauri Carakushansky, Eileen P.G. Vining

Research output: Contribution to journalArticle

Abstract

Seizures during the neonatal period have a broad differential diagnosis, many with a specific treatment and prognosis. In the case reported, a combination of dietary and endocrinologic abnormalities resulted in hypocalcemic seizures, which continued despite aggressive correction of serum ionized calcium levels. Serial electroencephalograms (EEG) performed during the hospitalization were markedly abnormal, and treatment with anticonvulsant drugs was considered given the persistence of seizures despite normalization of serum calcium levels. After 4 days of intravenous calcium administration, the seizure activity resolved, and the patient returned to his normal baseline level of functioning. This case highlights the clinical course of neonatal hypocalcemic seizures, EEG findings in several cases, and possible mechanisms for both hypocalcemic precipitation of seizures and anticonvulsant ineffectiveness.

Original languageEnglish (US)
Pages (from-to)236-239
Number of pages4
JournalJournal of Child Neurology
Volume17
Issue number3
StatePublished - 2002

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Seizures
Calcium
Anticonvulsants
Electroencephalography
Serum
Intravenous Administration
Hospitalization
Differential Diagnosis
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Neonatal hypocalcaemic seizures : Case report and literature review. / Kossoff, Eric H; Silvia, Mary T.; Maret, Alexander; Carakushansky, Mauri; Vining, Eileen P.G.

In: Journal of Child Neurology, Vol. 17, No. 3, 2002, p. 236-239.

Research output: Contribution to journalArticle

Kossoff, EH, Silvia, MT, Maret, A, Carakushansky, M & Vining, EPG 2002, 'Neonatal hypocalcaemic seizures: Case report and literature review', Journal of Child Neurology, vol. 17, no. 3, pp. 236-239.
Kossoff, Eric H ; Silvia, Mary T. ; Maret, Alexander ; Carakushansky, Mauri ; Vining, Eileen P.G. / Neonatal hypocalcaemic seizures : Case report and literature review. In: Journal of Child Neurology. 2002 ; Vol. 17, No. 3. pp. 236-239.
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