Neonatal erythropoiesis and subsequent anemia in HIV-positive and HIV-negative Zimbabwean babies during the first year of life: A longitudinal study

Melissa F. Miller, Jean H. Humphrey, Peter J. Iliff, Lucie C. Malaba, Nkosinathi V. Mbuya, Henry Chidawanyika, Agnes Mahomva, Florence Majo, Edmore Marinda, Michael Mbizvo, Lawrence Moulton, Kuda Mutasa, Mary Ndhlovu, Robert Ntozini, Ellen Piwoz, Lidia Propper, Philipa Rambanepasi, Andrea Ruff, Naume Tavengwa, Brian WardLynn Zijenah, Claire Zunguza, Partson Zvandasara, Kusum Nathoo, Jean Humphrey, Rebecca J. Stoltzfus

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Abstract

Background: Anemia is common in HIV infection and independently associated with disease progression and mortality. The pathophysiology of HIV-related anemia is not well understood especially in infancy. Methods: We conducted a longitudinal cohort study nested within the Zimbabwe Vitamin A for Mothers and Babies Project. We measured hemoglobin, erythropoietin (EPO), serum transferrin receptor (TfR) and serum ferritin at 6 weeks, 3 and 6 months of age and hemoglobin at 9 and 12 months in 3 groups of randomly selected infants: 136 born to HIV-negative mothers, and 99 born to HIV-positive mothers and who were infected themselves by 6 weeks of age, and 324 born to HIV-positive mothers but who did not become infected in the 6 months following birth. Results: At one year of age, HIV-positive infants were 5.26 (adjusted odds ratio, P

Original languageEnglish (US)
Article number1
JournalBMC Infectious Diseases
Volume6
DOIs
Publication statusPublished - Jan 3 2006

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ASJC Scopus subject areas

  • Infectious Diseases

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