Neonatal erythropoiesis and subsequent anemia in HIV-positive and HIV-negative Zimbabwean babies during the first year of life: A longitudinal study

Melissa F. Miller, Jean H. Humphrey, Peter J. Iliff, Lucie C. Malaba, Nkosinathi V. Mbuya, Henry Chidawanyika, Agnes Mahomva, Florence Majo, Edmore Marinda, Michael Mbizvo, Lawrence Moulton, Kuda Mutasa, Mary Ndhlovu, Robert Ntozini, Ellen Piwoz, Lidia Propper, Philipa Rambanepasi, Andrea Ruff, Naume Tavengwa, Brian WardLynn Zijenah, Claire Zunguza, Partson Zvandasara, Kusum Nathoo, Jean Humphrey, Rebecca J. Stoltzfus

Research output: Contribution to journalArticle

Abstract

Background: Anemia is common in HIV infection and independently associated with disease progression and mortality. The pathophysiology of HIV-related anemia is not well understood especially in infancy. Methods: We conducted a longitudinal cohort study nested within the Zimbabwe Vitamin A for Mothers and Babies Project. We measured hemoglobin, erythropoietin (EPO), serum transferrin receptor (TfR) and serum ferritin at 6 weeks, 3 and 6 months of age and hemoglobin at 9 and 12 months in 3 groups of randomly selected infants: 136 born to HIV-negative mothers, and 99 born to HIV-positive mothers and who were infected themselves by 6 weeks of age, and 324 born to HIV-positive mothers but who did not become infected in the 6 months following birth. Results: At one year of age, HIV-positive infants were 5.26 (adjusted odds ratio, P

Original languageEnglish (US)
Article number1
JournalBMC Infectious Diseases
Volume6
DOIs
StatePublished - Jan 3 2006

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Erythropoiesis
Longitudinal Studies
Anemia
HIV
Mothers
Hemoglobins
Zimbabwe
Transferrin Receptors
Ferritins
Erythropoietin
Serum
Vitamin A
HIV Infections
Disease Progression
Cohort Studies
Odds Ratio
Parturition
Mortality

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Neonatal erythropoiesis and subsequent anemia in HIV-positive and HIV-negative Zimbabwean babies during the first year of life : A longitudinal study. / Miller, Melissa F.; Humphrey, Jean H.; Iliff, Peter J.; Malaba, Lucie C.; Mbuya, Nkosinathi V.; Chidawanyika, Henry; Mahomva, Agnes; Majo, Florence; Marinda, Edmore; Mbizvo, Michael; Moulton, Lawrence; Mutasa, Kuda; Ndhlovu, Mary; Ntozini, Robert; Piwoz, Ellen; Propper, Lidia; Rambanepasi, Philipa; Ruff, Andrea; Tavengwa, Naume; Ward, Brian; Zijenah, Lynn; Zunguza, Claire; Zvandasara, Partson; Nathoo, Kusum; Humphrey, Jean; Stoltzfus, Rebecca J.

In: BMC Infectious Diseases, Vol. 6, 1, 03.01.2006.

Research output: Contribution to journalArticle

Miller, MF, Humphrey, JH, Iliff, PJ, Malaba, LC, Mbuya, NV, Chidawanyika, H, Mahomva, A, Majo, F, Marinda, E, Mbizvo, M, Moulton, L, Mutasa, K, Ndhlovu, M, Ntozini, R, Piwoz, E, Propper, L, Rambanepasi, P, Ruff, A, Tavengwa, N, Ward, B, Zijenah, L, Zunguza, C, Zvandasara, P, Nathoo, K, Humphrey, J & Stoltzfus, RJ 2006, 'Neonatal erythropoiesis and subsequent anemia in HIV-positive and HIV-negative Zimbabwean babies during the first year of life: A longitudinal study', BMC Infectious Diseases, vol. 6, 1. https://doi.org/10.1186/1471-2334-6-1
Miller, Melissa F. ; Humphrey, Jean H. ; Iliff, Peter J. ; Malaba, Lucie C. ; Mbuya, Nkosinathi V. ; Chidawanyika, Henry ; Mahomva, Agnes ; Majo, Florence ; Marinda, Edmore ; Mbizvo, Michael ; Moulton, Lawrence ; Mutasa, Kuda ; Ndhlovu, Mary ; Ntozini, Robert ; Piwoz, Ellen ; Propper, Lidia ; Rambanepasi, Philipa ; Ruff, Andrea ; Tavengwa, Naume ; Ward, Brian ; Zijenah, Lynn ; Zunguza, Claire ; Zvandasara, Partson ; Nathoo, Kusum ; Humphrey, Jean ; Stoltzfus, Rebecca J. / Neonatal erythropoiesis and subsequent anemia in HIV-positive and HIV-negative Zimbabwean babies during the first year of life : A longitudinal study. In: BMC Infectious Diseases. 2006 ; Vol. 6.
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AU - Iliff, Peter J.

AU - Malaba, Lucie C.

AU - Mbuya, Nkosinathi V.

AU - Chidawanyika, Henry

AU - Mahomva, Agnes

AU - Majo, Florence

AU - Marinda, Edmore

AU - Mbizvo, Michael

AU - Moulton, Lawrence

AU - Mutasa, Kuda

AU - Ndhlovu, Mary

AU - Ntozini, Robert

AU - Piwoz, Ellen

AU - Propper, Lidia

AU - Rambanepasi, Philipa

AU - Ruff, Andrea

AU - Tavengwa, Naume

AU - Ward, Brian

AU - Zijenah, Lynn

AU - Zunguza, Claire

AU - Zvandasara, Partson

AU - Nathoo, Kusum

AU - Humphrey, Jean

AU - Stoltzfus, Rebecca J.

PY - 2006/1/3

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