Neonatal alloimmune thrombocytopenia due to anti-HPA-5b (Bra)

Sally A. Campbell-Lee, Deirdre DeSantis-Parsons, R. Sue Shirey, Thomas S. Kickler

Research output: Contribution to journalArticle


Neonatal alloimmune thrombocytopenia (NAIT) results from maternal immunization against fetal platelet antigens and can occur during the first pregnancy. The most common complications of NAIT are neonatal thrombocytopenia, intracerebral hemorrhage, and fetal death. Most cases of NAIT in Causasians are caused by anti-HPA-1a (PlA1). Anti-HPA-5b (Bra) accounts for only 4.3 percent of all NAIT cases. NAIT due to anti-HPA-5b is thought to be milder and have fewer complications than NAIT caused by anti-HPA-1a because of the lower number of HPA-5b antigenic sites per platelet. This report describes a severe case of NAIT due to anti-HPA-5b that was treated by intrauterine platelet transfusion.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
Issue number4
StatePublished - Dec 12 2003


  • Br
  • HPA-5b
  • Neonatal alloimmune thrombocytopenia (NAIT)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology

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    Campbell-Lee, S. A., DeSantis-Parsons, D., Shirey, R. S., & Kickler, T. S. (2003). Neonatal alloimmune thrombocytopenia due to anti-HPA-5b (Bra). Immunohematology, 19(4), 127-131.