Neoadjuvant therapy followed by prostatectomy for clinically localized prostate cancer

Guru Sonpavde, Kim N. Chi, Thomas Powles, Christopher J. Sweeney, Noah Hahn, Thomas E. Hutson, Matthew D. Galsky, William R. Berry, Dov Kadmon

Research output: Contribution to journalReview article

Abstract

The results of this assessment of the literature indicated that neoadjuvant therapy followed by prostatectomy may improve long-term outcomes for patients with high-risk localized disease. In addition, this approach provides a paradigm for evaluating the activity and mechanism of action of new agents as correlative studies are facilitated by the availability of tumor tissue before and after therapy. The authors determined that a multidisciplinary approach involving oncologists, urologists, and pathologists is critical to the success of this model. Recent and ongoing studies of neoadjuvant therapy followed by prostatectomy were reviewed.

Original languageEnglish (US)
Pages (from-to)2628-2639
Number of pages12
JournalCancer
Volume110
Issue number12
DOIs
StatePublished - Dec 15 2007
Externally publishedYes

Keywords

  • Biologic therapy
  • Chemotherapy
  • Hormonal therapy
  • Multidisciplinary approach
  • Neoadjuvant therapy
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Sonpavde, G., Chi, K. N., Powles, T., Sweeney, C. J., Hahn, N., Hutson, T. E., Galsky, M. D., Berry, W. R., & Kadmon, D. (2007). Neoadjuvant therapy followed by prostatectomy for clinically localized prostate cancer. Cancer, 110(12), 2628-2639. https://doi.org/10.1002/cncr.23085