Neoadjuvant chemoradiation therapy is beneficial for clinical stage T2 N0 esophageal cancer patients due to inaccurate preoperative staging

Jennifer Q. Zhang, Craig M. Hooker, Malcolm V. Brock, James Shin, Sue Lee, Remealle How, Noreli Franco, Helen Prevas, Alicia Hulbert, Stephen C. Yang

Research output: Contribution to journalArticlepeer-review

Abstract

Background: It remains unclear if patients with clinical stage T2 N0 (cT2 N0) esophageal cancer should be offered induction therapy vs surgical intervention alone. Methods: This was a retrospective cohort study of cT2 N0 patients undergoing induction therapy, followed by surgical resection, or resection alone, at the Johns Hopkins Hospital from 1989 to 2009. Kaplan-Meier analysis was used to compare all-cause mortality in cT2 N0 patients who had resection alone vs those who had induction chemoradiation therapy, followed by resection. Results: A study cohort of 69 patients was identified and divided into two groups: 55 patients (79.7%) received induction therapy and 14 (20.3%) did not. No statistically significant difference in 5-year survival rate was observed for the two groups: 49.5% for the resection-only group and 53.8% for the induction group. More than 50% of cT2 N0 patients were understaged. Conclusions: For cT2 N0 esophageal cancer patients, the benefit of neoadjuvant therapy is still unclear. Induction therapy for cT2 N0 did not translate into a statistically significant improvement in survival. However, due to the significant understaging of T2 N0 patients, we recommend neoadjuvant therapy to all cT2N0 patients before operation.

Original languageEnglish (US)
Pages (from-to)429-437
Number of pages9
JournalAnnals of Thoracic Surgery
Volume93
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • ASA
  • American Society of Anesthesiologists
  • CI
  • CT
  • EUS
  • HR
  • IQR
  • PET
  • R0
  • R1
  • cT2 N0
  • clinical stage T2 N0
  • computed tomography
  • confidence interval
  • endoscopic ultrasound
  • hazard ratio
  • interquartile range
  • margin negative
  • margin positive
  • pT2 N0
  • pathologic stage T2 N0
  • positron emission tomography

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Neoadjuvant chemoradiation therapy is beneficial for clinical stage T2 N0 esophageal cancer patients due to inaccurate preoperative staging'. Together they form a unique fingerprint.

Cite this