Neoadjuvant Breast Cancer Trials: Translational Research in Drug Development

Julia A. Beaver; Laleh Amiri-Kordestani; Reena Philip; Patricia Cortazar

doi:10.1007/s12609-015-0183-2

Neoadjuvant Breast Cancer Trials: Translational Research in Drug Development

Julia A. Beaver, Laleh Amiri-Kordestani, Reena Philip, Patricia Cortazar

Research output: Contribution to journal › Review article › peer-review

Abstract

In addition to reducing the size and extent of locally advanced breast cancer tumors, neoadjuvant trials allow for rapid assessment of drug efficacy and could expedite development and approval of treatments for early breast cancer. For these reasons, clinical trials in the neoadjuvant setting are prime opportunities to study translational science, pathologic response, genetic biomarkers, and imaging biomarkers. In this review, we provide a summary of the efforts to identify biomarkers aimed to understand tumor biology and to prognosticate and predict response to neoadjuvant therapy for early breast cancer. We also provide a perspective on how neoadjuvant trials can be used to pursue translational research and drug development.

Original language	English (US)
Pages (from-to)	151-160
Number of pages	10
Journal	Current Breast Cancer Reports
Volume	7
Issue number	3
DOIs	https://doi.org/10.1007/s12609-015-0183-2
State	Published - Sep 24 2015
Externally published	Yes

Keywords

Assessment
Biomarkers
Clinical trials
Drug development
Drug efficacy
Neoadjuvant trials

ASJC Scopus subject areas

Oncology

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10.1007/s12609-015-0183-2

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title = "Neoadjuvant Breast Cancer Trials: Translational Research in Drug Development",

abstract = "In addition to reducing the size and extent of locally advanced breast cancer tumors, neoadjuvant trials allow for rapid assessment of drug efficacy and could expedite development and approval of treatments for early breast cancer. For these reasons, clinical trials in the neoadjuvant setting are prime opportunities to study translational science, pathologic response, genetic biomarkers, and imaging biomarkers. In this review, we provide a summary of the efforts to identify biomarkers aimed to understand tumor biology and to prognosticate and predict response to neoadjuvant therapy for early breast cancer. We also provide a perspective on how neoadjuvant trials can be used to pursue translational research and drug development.",

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AU - Beaver, Julia A.

AU - Amiri-Kordestani, Laleh

AU - Philip, Reena

AU - Cortazar, Patricia

PY - 2015/9/24

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N2 - In addition to reducing the size and extent of locally advanced breast cancer tumors, neoadjuvant trials allow for rapid assessment of drug efficacy and could expedite development and approval of treatments for early breast cancer. For these reasons, clinical trials in the neoadjuvant setting are prime opportunities to study translational science, pathologic response, genetic biomarkers, and imaging biomarkers. In this review, we provide a summary of the efforts to identify biomarkers aimed to understand tumor biology and to prognosticate and predict response to neoadjuvant therapy for early breast cancer. We also provide a perspective on how neoadjuvant trials can be used to pursue translational research and drug development.

AB - In addition to reducing the size and extent of locally advanced breast cancer tumors, neoadjuvant trials allow for rapid assessment of drug efficacy and could expedite development and approval of treatments for early breast cancer. For these reasons, clinical trials in the neoadjuvant setting are prime opportunities to study translational science, pathologic response, genetic biomarkers, and imaging biomarkers. In this review, we provide a summary of the efforts to identify biomarkers aimed to understand tumor biology and to prognosticate and predict response to neoadjuvant therapy for early breast cancer. We also provide a perspective on how neoadjuvant trials can be used to pursue translational research and drug development.

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KW - Drug efficacy

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Neoadjuvant Breast Cancer Trials: Translational Research in Drug Development

Abstract

Keywords

ASJC Scopus subject areas

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